[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
Publication Ethics::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing & Abstracting
DOAJ
GOOGLE SCHOLAR
..
:: Volume 20, Issue 5 (8-2015) ::
__Armaghane Danesh__ 2015, 20(5): 404-415 Back to browse issues page
The Effect of Hydroalcoholic Extract of Nectaroscordum Tripedale on Biochemical Factors in Diabetic Rats
S Paydar1 , GA Jelodar1 , J Mohammadi 2
1- 1Department of physiology, School of Veterinary, Shiraz University, Shiraz, Iran,
2- 2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran , J_mohammadi2005@yahoo.com
Abstract:   (7825 Views)
Background & aim: The therapeutic effects of traditional medicinal plants used in traditional medicine for many diseases have been proved. The present study was undertaken to investigate the effect of oral administration of different doses of hydroalcoholic extract of Nectaroscordum tripedale on biochemical factors. Method: Forty adult male Sprague Dawley rats were randomly divided into five groups of 8 animals as follows control group (recieved distilled water), control +50 mg/kg Nectaroscordum tripedale, diabetic control group (recieved distilled water), treatment group 1 (recieved 50mg/kg Nectaroscordum tripedale), treatment group 2 (recieved 100 mg/kg Nectaroscordum tripedales). The animals recieved Nectaroscordum tripedales extract by gavage for 21 days. Diabetes was induced by a single injection streptozotocin in rat (50 mg/kg b.w., ip). Before and 3 days after injection, 7, 14 and 21 days of treatment, the fasting glucose level and weight was measured. At the end of 21 days, blood samples collected from the heart puncture, after animals anesthetized with ether. The blood samples were analysed for lipid profile (total cholesterol, TG, HDL-c, LDL-c). Results: The results showed that the hydroalcoholic extract of Nectaroscordum tripedale could increase the average weight and decrease glucose in this period and also reduce cholesterol levels, triglyceride, and LDL-c dose dependent reduction at the end of 21 days (P <0/05). The hydroalcoholic extract of Nectaroscordum tripedale showed an overall beneficial effect on serum lipid profiles and biochemical factors. Conclusion: Nectaroscordum tripedale may act as an antidiabetic agent by increasing either the pancreatic secretion of insulin from the pancreas or its release from bound insulin and increasing insulin and improving pancreatic function. Moreover, the antioxidant properties may reduce the hydroxy-3-methyl-glutaryl-CoA reductase.
Keywords: Diabetes mellitus, Nectaroscordum tripedale, lipid profile, rat
Full-Text [PDF 184 kb]   (1292 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/07/5 | Accepted: 2015/07/5 | Published: 2015/07/5
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Paydar S, Jelodar G, Mohammadi J. The Effect of Hydroalcoholic Extract of Nectaroscordum Tripedale on Biochemical Factors in Diabetic Rats. armaghanj 2015; 20 (5) :404-415
URL: http://armaghanj.yums.ac.ir/article-1-945-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 5 (8-2015) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4645