[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
Publication Ethics::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing & Abstracting
DOAJ
GOOGLE SCHOLAR
..
:: Volume 18, Issue 10 (1-2014) ::
__Armaghane Danesh__ 2014, 18(10): 847-858 Back to browse issues page
Growth Factor and Laminin Effect with Muscular Fiber Sheath on Repairing of the Sciatica Nerve
S Torabi , R Mahmoudi , A Rozbehi , M Jafari Barmak , P Rad , H Delaviz 1
1- , Hamdidelaviz@yahoo.com
Abstract:   (4480 Views)
Abstract Background & aim: Peripheral nerve injuries which can lead to a physical disability. If the defect is very low, direct suture without tension on both ends of the cut nerve regeneration is considered as a standard procedure. Otherwise, to reconstruct the axons, the gap must be filled by graft material in order to the guidance. Due to the similarity of the matrix tubular skeletal muscle and nerve muscles graft was used to repair in this study. Methods: In the present experimental study, 42 female Wistar rats were divided into three groups and underwent surgery. In the first group a narrow strip of muscle was prepared by freezing – thawing, and later sutured between the distal and proximal sciatic nerve. In the second group, the gap caused by muscle graft was regenerated and the nerve growth factor and laminin was injected into the graft. In the control group, the two ends of the cut nerve were hidden beneath the adjacent muscles. Next, a group of rats with sciatic functional index was investigated for the behavioral. On the other group were examined for histological studies after two months. Results: Sciatic functional index and Mean counts of myelinated fibers in two graft groups compared with the control group was significant) p<0.05). Statistical analysis was performed using ANOVA test. Conclusion: co-axially aligned muscle grafts were an appropriate alternative substitute for repairing. It seems that the nerve growth factor and laminin have a positive role in axonal regeneration and functional recovery acceleration. Key words: Sciatic Functional Index, muscle graft, NGF, Laminin
Keywords: Key words: Sciatic Functional Index, muscle graft, NGF, Laminin
Full-Text [PDF 529 kb]   (1345 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/05/6 | Accepted: 2015/05/6 | Published: 2015/05/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Torabi S, Mahmoudi R, Rozbehi A, Jafari Barmak M, Rad P, Delaviz H. Growth Factor and Laminin Effect with Muscular Fiber Sheath on Repairing of the Sciatica Nerve. armaghanj 2014; 18 (10) :847-858
URL: http://armaghanj.yums.ac.ir/article-1-494-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 10 (1-2014) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645