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Analgesic effects of alpha-pinene on pain models of writing and plantar tests in rats
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Akram Ebrahimifar  , Helia Rahmani , Kaveh Rahimi 1, Esmail Izadpanah , Abbas Ahmadi |
| 1- , kaveh_rahimi66a@yahoo.com |
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Abstract: (42 Views) |
Background: The aim of this study was to evaluate the analgesic effects of Alpha Pinene in writing and plantar pain tests in rats.
Methods: This study was performed on male Wistar rats. Group 1: Normal saline was administered intraperitoneally (IP). Group 2: Diclofenac sodium at a dose of 5 mg/kg was administered (IP). Group 3: Alpha Pinene was administered (IP) at a dose of 0.1 mg/kg. Group 4: Alpha Pinene was administered (IP) at a dose of 5 mg/kg. Group 5: Alpha Pinene was administered intraperitoneally at a dose of 10 mg/kg. Then writing and plantar tests (five groups for each test) were performed.
Results: The results showed that in the writing test, the number of abdominal twists in the groups that received alpha pinene was significantly lower than the control group (P<0.05). Also, in the writing test, diclofenac sodium 5 mg decreased pain intensity compared to the control group (P<0.05). In the plantar test, the pain intensity in the groups that received alpha pinene 5 mg/kg and diclofenac sodium 5 mg was significantly lower than the control group (P<0.05).
Conclusion: Alpha Pinene in doses of 5 and 10 mg/kg can reduce the severity in the visceral pain model of writing test. Also, at 30 and 60 minutes in the plantar test Alpha Pinene at a dose of 5 mg/kg, like diclofenac sodium (at a dose of 5 mg) can reduce pain. |
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| Keywords: Alpha Pinene, Acetic acid, Writing test, Plantar test, Rat. |
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Type of Study: Research |
Subject:
Physiology
Received: 2022/10/15 | Accepted: 2023/04/8 | Published: 2023/05/6
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