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:: Volume 26, Issue 2 (4-2021) ::
__Armaghane Danesh__ 2021, 26(2): 0-0 Back to browse issues page
Production of carotenoid biotechnology by the yeast Rhodoturola glutinis and evaluation of its hepatic function in male mice
Mahbouube Mousavi Miss1 , Nooshin Naghsh Dr 2, Mahbouube Madan Dr1
1- Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2- Falavarjan Branch, Islamic Azad University, Isfahan, Iran , n_naghsh@yahoo.com
Abstract:   (124 Views)
Abstract
Introduction: Carotenoids have received much attention due to their conversion to vitamin A in the body, reducing the risk of destructive diseases, antioxidant activity, improving immune function and their application as edible colors.
Methods: In this quasi-experimental study, carotenoids were extracted from Rhodotorula glutinis by Davis method. 24 male mice were randomly divided into 3 groups of 8 each. The two groups received carotenoids 32 mg/kg and 16 mg/kg peritoneally. The control group received 0.5 ml Distilled water intraperitoneally. Blood samples were taken and liver toxicity was assessed by GGT, ALP, SGOT and SGPT factors. The results were analyzed by SPSS 21 software and all data were compared by ANOVA.
Results: In this study, the amount of carotenoids isolated from the yeast of Rhodoturola glutenis was equal to 0.1 mg/L and the results of the related food industry with a purity of: 12.21 mg%, moisture content of 18 mg/L, ash. Total: 9.6 mg percent, volatiles: 9.8 mg percent, acid number 7.3 mg percent and pH: 5.5.  The mean activity of SGOT, SGPT, ALP in the 32 and 16mg/kg injections was not significantly different with the control group. Also. the mean of GGT activity in the 32mg/kg treated group was significantly less than the 16mg/kg injection group.
Conclusion: According to the results of this study, Rhodotorula glutinis carotenoids was not significantly different in liver enzyme activity in treatment and control group. Also, the GGT activity is an important marker of oxidative stress. The mean of GGT activity in the 32mg/kg injection group was significantly less than other group which this decrease probability can be attributed to the effect of the dose dependent of the carotenoids caused decrease the oxidative stress in the 32mg/kg injection group. Also, it could be suggested to use it in the pharmaceutical and food industries.
Keywords: Rhodotorula glutinis yeast, Carotenoid, Liver toxicity, Mice
     
Type of Study: Research | Subject: Physiology
Received: 2020/12/10 | Accepted: 2021/04/24 | Published: 2021/05/8
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Mousavi M, Naghsh N, Madan M. Production of carotenoid biotechnology by the yeast Rhodoturola glutinis and evaluation of its hepatic function in male mice. Armaghane danesh. 2021; 26 (2)
URL: http://armaghanj.yums.ac.ir/article-1-2995-en.html


Volume 26, Issue 2 (4-2021) Back to browse issues page
ارمغان دانش Armaghane danesh
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