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:: Volume 26, Issue 4 And ضمیمه 1 (9-2021) ::
__Armaghane Danesh__ 2021, 26(4 And ضمیمه 1): 634-645 Back to browse issues page
The Effect of Endurance Training on Increase of myoD Gene Expression in Rat Slow and Fast-Twitch Muscles
M Fathi 1, S Ahmadabadi2
1- Department of Physical Education & Sport Sciences, Lorestan University. Khorramabad, Iran , fathi.m@lu.ac.ir
2- Department of Physical Education & Sport Sciences, Farhangian University, Tehran, Iran
Abstract:   (1077 Views)
Background & aim: The increase of myoD gene expression is the characteristic of activation and proliferation of satellite cells due to induced stimulus in skeletal muscle. But it seems the fast and slow skeletal muscle response and the appearance of this marker due to stimulus are not similar. Accordingly, the present study aimed to evaluate the effect of endurance training on myoD gene expression in fast and slow skeletal muscle in Wistar male rats.
 
Methods: In the present study conducted in 2020, 14 rats (weight 234±24g) provided from Pasteur Institute and housed under natural conditions (temperature, light/dark (12-h) cycle, with ad Libitum access to food and water). The rats randomly divided to two groups experimental (n=7) and control (n=7); the experimental group performed an endurance training program (30 m/min, 50 min, 6 sessions per week for 14-weeks) on a motorized treadmill, and 48 hours after the end of the last session of endurance activity with the control group were anesthetized and sacrificed, then the soleus and extensor digitorum longus (EDL) muscles were removed. Real-time RT-PCR was used to determine if expression levels of myoD gene. To conclude, the data were analyzed by independent t-test.
 
Results: endurance training induced a significant increase (p=0.022) in EDL myoD gene expression; correspondingly, this modification was observed in soleus muscles (p=0.001)
Conclusion: it appeared that endurance training increased the myoD gene expression in soleus (slow-twitch muscle) and EDL (fast-twitch muscle).
 
Keywords: Endurance activity, myoD, Extensor Digitorum Longus and Soleus Muscle
Full-Text [PDF 774 kb]   (295 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2020/07/24 | Accepted: 2020/10/10 | Published: 2021/09/6
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Fathi M, Ahmadabadi S. The Effect of Endurance Training on Increase of myoD Gene Expression in Rat Slow and Fast-Twitch Muscles. armaghanj 2021; 26 (4) :634-645
URL: http://armaghanj.yums.ac.ir/article-1-2863-en.html


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Volume 26, Issue 4 And ضمیمه 1 (9-2021) Back to browse issues page
ارمغان دانش Armaghane Danesh
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