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:: Volume 26, Issue 4 And ضمیمه 1 (9-2021) ::
__Armaghane Danesh__ 2021, 26(4 And ضمیمه 1): 0-0 Back to browse issues page
Increase of myoD gene expression in slow and fast twitch muscles due to Endurance Training
Mohammad Fathi 1, Somayeh Ahmadabadi2
1- lorestan university , fathi.m@lu.ac.ir
2- Farhangiyan
Abstract:   (75 Views)
Background and Objective: The increase of myoD gene expression is the characteristic of activation and proliferation of satellite cells due to induced stimulus in skeletal muscle. But it seems the fast and slow skeletal muscle response and the appearance of this marker due to stimulus are not similar. Thus, this study aimed to evaluate the effect of endurance training on myoD gene expression in fast and slow skeletal muscle in Wistar male rats

Materials and Methods: 4 rats (weight 234±24g) prepared from Pasteur Institute and housed under natural conditions (temperature, light/dark (12-h) cycle, with ad Libitum access to food and water). The rats randomly divided to two groups experimental (n=7) and control (n=7); the experimental group performed an endurance training program (30 m/min, 50 min, 6 sessions per week for 14-weeks) on a motorized treadmill, and 48 hours after the end of the last session of endurance activity with the control group were anesthetized and sacrificed, then the soleus and extensor digitorum longus (EDL) muscles were removed. Real-time RT-PCR was used to determine if expression levels of myoD gene, finally, the data were analyzed by t-test.

Results: the result of this study showed that endurance activity induces a significant increase (p=0.022) in EDL myoD gene expression. Also the myoD gene expression in soleus due to endurance activity increase significantly (p=0.001)
Conclusion: it seems the myoD gene expression in slow-twitch muscle than in fast-twitch muscle is more affected by resistance exercise.
Keywords: Endurance activity, myoD, Extensor digitorum longus and Soleus muscle
Type of Study: Research | Subject: Sport Physiology
Received: 2020/07/24 | Accepted: 2020/10/10 | Published: 2021/09/6
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fathi M, ahmadabadi S. Increase of myoD gene expression in slow and fast twitch muscles due to Endurance Training. Armaghane danesh. 2021; 26 (4)
URL: http://armaghanj.yums.ac.ir/article-1-2863-en.html

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Volume 26, Issue 4 And ضمیمه 1 (9-2021) Back to browse issues page
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