The Effects of 8 Weeks Aerobic Training and Vitamins E & C Supplementation on the Plasma Levels of MMP-2 and MMP-9 in Patients with Coronery Heart Desease

Karmi,  E; Shabani , R; Rahmaniya , F; Elmiye , A; Rezagholizadeh , M

doi:10.61186/armaghanj.30.1.1

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Volume 30, Issue 1 (1-2025)

__Armaghane Danesh__ 2025, 30(1): 1-17

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The Effects of 8 Weeks Aerobic Training and Vitamins E & C Supplementation on the Plasma Levels of MMP-2 and MMP-9 in Patients with Coronery Heart Desease

E Karmi¹

, R Shabani²

, F Rahmaniya³

, A Elmiye¹

, M Rezagholizadeh⁴

1- Department of Physical Education and Sport Sceinces, Rasht branch, Islamic Azad University, Rasht, Iran,
2- Department of Physical Education and Sport Sceinces, Rasht branch, Islamic Azad University, Rasht, Iran, , dr.ramin.shabani@gmail.com
3- Faculty of Physical Education and Sports Sciences, Guilan University, Guilan, Iran,
4- Department of physical Education and Sport Sceinces, Zanjan Branch, Islamic Azad University, Zanjan, Iran

Abstract: (1136 Views)

Background & aim: Coronary heart disease is one of the most important causes of death in most countries. Regular exercise and vitamin supplementation are useful solutions in improving cardiovascular diseases. The matrix metalloproteinase family plays an important role in the occurrence of cardiovascular diseases and the reconstruction of the vascular wall. The purpose of the present study was to investigate the effect of eight weeks of aerobic training with vitamin E and C supplementation on the plasma levels of matrix metalloproteinas2 and matrix metalloproteinas9 in patients with coronary artery disease.

Methods: The present clinical trial study was conducted at the specialized cardiac rehabilitation center of Bahman Hospital located in Zanjan in the year 2021 with a pre-test/post-test design. Sixty patients (both male and female) with CAD were selected to participate in the present research. The subjects were randomly assigned to four groups of 15 individuals each (exercise + supplement, exercise, supplement, and control). The participants received one gram of di-alpha-tocopherol and one gram of ascorbic acid daily. The exercise program included eight weeks (three sessions per week) of aerobic activity at an intensity of 40 to 80 percent of reserve heart rate for 45 minutes, utilizing a treadmill, stationary bike, and hand ergometer. Anthropometric assessments were performed 24 hours before the first exercise session and 24 hours after the last exercise session, and blood samples were collected. The collected data were analyzed using statistical tests such as covariance analysis, Bonferroni post-hoc test, paired t-test, Shapiro-Wilk test, Levene's test, and linear regression.

Results: The results indicated that the level of MMP-2 in the plasma of patients with CAD was significantly higher in the aerobic training group with vitamin E and C supplementation than in the aerobic training group (p=0.001). Also, the level of MMP-9 in the plasma of patients with CAD in the aerobic training group with vitamin E and C supplementation was significantly lower than the aerobic training group (p=0.001).

Conclusion: combined aerobic training and taking vitamin E and C supplements can affect the plasma levels of the mentioned indicators to a greater extent and cause them to improve, which displays the higher efficiency of training at the same time as the supplement.

Keywords: Coronary artery disease, Aerobic training, Vitamin E and C supplementation, Matrix metalloproteinases.

Full-Text [PDF 551 kb] (35 Downloads)

Type of Study: Research | Subject: Sport Physiology
Received: 2024/06/11 | Accepted: 2024/10/5 | Published: 2025/02/4

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Karmi E, Shabani R, Rahmaniya F, Elmiye A, Rezagholizadeh M. The Effects of 8 Weeks Aerobic Training and Vitamins E & C Supplementation on the Plasma Levels of MMP-2 and MMP-9 in Patients with Coronery Heart Desease. armaghanj 2025; 30 (1) :1-17
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