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Association of COVID-19 infection with liver tests and pregnancy outcomes: A prospective cohort study
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Mansoureh Yazdkhasti   1, Mina Valizadeh2 , Zohreh Mahmoodi2 , Mahmood Bakhtiari2 , Mehdi Mosavian2 |
1- ABZUMS , Mansoyazd@yahoo.com
2- ABZUMS |
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Abstract: (422 Views) |
Background and purpose: With the spread of the new virus, COVID-19, there were many concerns about the effects and complications of pregnant women contracting this virus. Since pregnant women are in a vulnerable group due to the physiological changes associated with pregnancy, the present study was conducted to relate the infection of COVID-19 with liver tests and pregnancy outcomes.
Methodology: This prospective cohort study was conducted from October 2019 to September 2011 in Shahid Akbarabadi and Firouzgar educational centers in Tehran. One hundred ninety-one eligible people were included in the study by available method and then by simple random allocation. Data was collected by demographic and fertility questionnaires, pain (VAS), and related checklists. Data analysis was done using SPSS 26 software and through t-test, Mann-Whitney, chi-square, and exact test. Fisher, Spearman, Pearson, and logistic regression were performed.
Findings: The number of liver tests (international normalized ratio (INR), aspartate aminotransferase (AST), and alanine aminotransferase (ALT, ALP, alkaline phosphatase) increased between the two groups. This increase between the two groups had a statistically significant difference (p<0.001). However, the average platelet, indirect bilirubin, and relative thromboplastin time in the case group were significantly lower than the control group (P<0.002, P<0.001, P<0.041). ). Also, premature delivery and the intensity of contractions in the case and control groups had a statistically significant difference (p<0.001). No statistically significant difference was observed in the type of delivery in the case and control groups. Being infected with COVID-19, the risk of alkaline phosphatase (Increased ALP by 15% and the risk of indirect bilirubin by 58%, which was reported to be statistically significant, but it did not affect platelets and the International Normalized Ratio (INR).
Conclusion: Based on the findings of our study, the infection of COVID-19 caused liver tests to be disturbed. Disruption of liver tests due to COVID-19 infection can overlap the changes made during pre-eclampsia syndrome or HELLP syndrome (hemolysis, increase of liver enzymes, decrease of platelets). Also, getting infected with COVID-19 increases the intensity of contractions and premature delivery. Therefore, it is suggested that Their liver function tests are carefully monitored, and effective interventions are carried out to prevent premature birth.
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| Keywords: COVID-19, pregnancy, liver tests, pregnancy outcome |
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Type of Study: Research |
Subject:
Clinical
Received: 2023/09/29 | Accepted: 2024/09/25 | Published: 2024/10/6
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