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Indexing & Abstracting
:: Volume 26, Issue 5 (11-2021) ::
__Armaghane Danesh__ 2021, 26(5): 838-850 Back to browse issues page
Evaluation of the Effects of Phototherapy on Neonatal Serum Magnesium Levels: A Systematic Review
M Nabi Meybodi1 , H Parsai 2, GH Abdollahi Fard3 , SSH Mousavi1
1- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , hparsaee@gmail.com@gmail.com
3- Departments of Social Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (1321 Views)
Background & aim: Neonatal jaundice with a prevalence of 60% in the first weeks of life is one of the most common neonatal diseases that occurs due to elevated serum bilirubin levels. Phototherapy is the most common method for the treatment of neonatal jaundice, since the effect of phototherapy on serum magnesium levels in infants is not well understood, as a result, the aim of the present study was to determine the effect of phototherapy on serum magnesium levels in neonatal hyperbilirubinemia.
Methods: In the present systematic review article in 2021, domestic databases of University Jihad, Civilica, and university journals in addition to PubMed database were searched without time limit. Studies which assessed the effect of phototherapy on serum magnesium level were reviewed and the results were reported. All articles were separately reviewed by two authors. The data were interpreted through comparative analysis.
Results: Magnesium serum level was measured in less than 24 hours after phototherapy in eight studies, 48 hours in four, and 72 hours in three. Two hundred and twenty-two articles were extracted from the mentioned databases. Applying the inclusion and exclusion criteria, 14 articles were selected for thorough assessment. As shown in most of these studies, phototherapy had a significant effect on decreasing serum magnesium levels in neonates. Only one study did not show any significant effect. Most studies have not evaluated demographic and clinical variables in decreasing serum magnesium levels.
Conclusion: There was a significant relationship between phototherapy and serum magnesium levels. Considering the role of NMDA receptor and its stimulatory effect in brain damage due to hypoxia and hyperbilirubinemia and the importance of magnesium in its inhibition, the body increases the extracellular magnesium levels during neonatal jaundice to prevent brain damage. It was concluded that after phototherapy, and therefore resolution of hyperbilirubinemia, serum magnesium level was reduced.
Keywords: Phototherapy, Serum magnesium, Hyperbilirubinemia, Systematic review
Full-Text [PDF 819 kb]   (380 Downloads)    
Type of Study: Review Article | Subject: Clinical
Received: 2021/04/8 | Accepted: 2021/11/1 | Published: 2021/11/8
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Nabi Meybodi M, Parsai H, Abdollahi Fard G, Mousavi S. Evaluation of the Effects of Phototherapy on Neonatal Serum Magnesium Levels: A Systematic Review. armaghanj 2021; 26 (5) :838-850
URL: http://armaghanj.yums.ac.ir/article-1-3057-en.html

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Volume 26, Issue 5 (11-2021) Back to browse issues page
ارمغان دانش Armaghane Danesh
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