[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 25, Issue 1 (2-2021) ::
__Armaghane Danesh__ 2021, 25(1): 0-0 Back to browse issues page
The effect of aerobic exercise on epicardial adipose tissue, insulin resistance, and some liver enzymes in high-fat diet-induced obesity male wistar rat
Ebrahim Moslehi Najafabadi1 , Vazgen Minasian Dr 2, Heibatollah Sadeghi Dr3
1- University of Isfahan
2- University of Isfahan , v.minasian@spr.ui.ac.ir
3- Yasuj University of Medical Sciences
Abstract:   (844 Views)
Background and Aim: Due to the prevalence and socio-economic consequences of obesity in mortality, cardiovascular (CAD) and nonalcoholic fatty liver disease the effectiveness of aerobic exercise on epicardial adipose tissue (EAT), insulin resistance (IR) and some liver enzymes of high-fat diet-induced obesity male wistar rats was investigated.
Methods: Thirty-two male Wistar rats with an average weight of 180-200 gr were randomly assigned into 4 equal groups: Normal Fat Diet (NFD), High-Fat Diet induced obesity (HFDO), Normal Fat Diet after High-Fat Diet induced obesity (HFDO-NFD) and Aerobic Exercise group with normal fat diet after High-Fat Diet induced obesity (HFDO-AEX). Body composition, fasting levels of Serum insulin, FBS, IR, TG, LDL, HDL, Cholesterol, AST, ALT, ALKP evaluated. Samples in the HFDO group were taken after fatty liver induced and in other groups 48 hours after eight weeks of aerobic training.
Results: Results showed that after high-fat diet (HFD) period in comparison with the NFD group, Lee index, EAT, fasting blood glucose, insulin resistance, blood lipid profile and liver enzymes AST, ALT, ALP significantly increased (P ≤ 0.001). Also, eght weeks of aerobic training also significantly improved the values of Lee index (18.34%), relative EAT values (76.19%), insulin (4.01%), insulin resistance (37.48%), Fasting blood glucose (32.28%), HDL-c (23.65%), LDL-c (41.37%), total cholesterol (24.68%) and TG (49.55%) as well as liver enzymes AST (45.9%), ALT (44.34%), ALP (11.5%) tended to baseline values (P ≤ 0.001).
Conclusion: These data suggested that aerobic exercise by an improvement in the insulin resistance, blood lipid profiles and EAT fat mas can alter the liver metabolism and attenuates predictive cardiovascular risk factor.
 
Keywords: The effect of aerobic exercise on epicardial fat, liver and insulin resistance in obesity
     
Type of Study: Research | Subject: Sport Physiology
Received: 2019/07/31 | Accepted: 2019/09/2 | Published: 2020/03/4
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moslehi Najafabadi E, Minasian V, Sadeghi H. The effect of aerobic exercise on epicardial adipose tissue, insulin resistance, and some liver enzymes in high-fat diet-induced obesity male wistar rat. Armaghane danesh. 2021; 25 (1)
URL: http://armaghanj.yums.ac.ir/article-1-2587-en.html


Volume 25, Issue 1 (2-2021) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4071