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The Analgesic Effect of Sour Cherry Kernel Extract in male Rat
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M Mahmoodi1    , H Vazini 2, S Shahidi3 , HR Ghiyayi1 , P Notghi1 |
1- Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran
2- Nursing Department, Islamic Azad University, Hamedan Branch, Hamedan, Iran , hosseinvazini@gmail.com
3- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. |
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Abstract: (3099 Views) |
Background & Aim: For many years, several substances have been used, such as morphine, as a pain reliever, Depending on the addictive characteristics and side effects; there is less willingness to use them. Today, the use of herbal medicines has expanded. Therefore, research to find analgesic drugs are considered necessary. The aim of this study was to evaluate the analgesic effect of alcoholic extract of the core is made of cherry in male rat.
Methods: In this study, 36 male rats were divided into 6 groups of 6: control (normal saline 1mg/kg), morphine (1mg/kg), cherry kernel extract (100, 150, 250 mg/kg, I.P) and the group treated with Naloxone (1mg/kg), in combination with low doses of cranberry seed extract (150 mg/kg) were divided. Then, to assess the anti-nociceptive effects of the extract, we used Writhing and Tail-flick tests.
Results: The results of the study showed that the extract significantly inhibited the number of contractions induced by acetic acid. The results of Tail-flick test showed that the delay time of tail removal after injection in all groups was significantly associated with latency of tail withdrawal before injection (P <0.05). The extract group with a dose of 250 (mg / kg body weight) showed more analgesic effects than other doses of the extract and the mean delay in this group was significantly higher than other doses (P <0.05).
Conclusion: According to the present results, the Sour Cherry Extract kernel have analgesic effects. The presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.
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| Keywords: Rat, Cherry pit, Pain |
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Full-Text [PDF 209 kb]
(757 Downloads)
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Type of Study: Research |
Subject:
Physiology
Received: 2017/11/17 | Accepted: 2018/07/19 | Published: 2018/08/3
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