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:: Volume 23, Issue 3 (8-2018) ::
__Armaghane Danesh__ 2018, 23(3): 0-0 Back to browse issues page
The analgesic effect of alcoholic extract of sour Cherry pit in male rat
Minoo Mahmoodi Dr1 , Hossein Vazini Dr 2, Siamak Shahidi 3 , Hamidreza Ghiyayi Mr4 , Parmis Notghi Mrs4
1- Assistant Professor Islamic Azad University, Hamedan Branch
2- Assistant Professor Islamic Azad University, Hamedan Branch , hosseinvazini@gmail.com
3- Professor Bu-Ali Sina University, Hamedan, Iran.
4- MSc Islamic Azad University, Hamedan Branch
Abstract:   (169 Views)
BACKGROUND: For many years, several substances have been used, such as morphine, as a pain reliever. Depending on the addictive characteristics and side effects, there is less willingness to use them. Today, the use of herbal medicines has expanded. Therefore, doing research to find analgesic drugs is considered necessary. The aim of this study was to evaluate the analgesic effect of alcoholic extract of sour Cherry pit in male rat.
METHODS: In this study, 36 male rats were divided into 6 groups of 6, including: control group (normal saline, 1mg/kg), experimental group (morphine, 1mg/kg), those group that have been treated with sour cherry pit extract (100, 150, 250 mg/kg, I.P) and the group treated with Naloxone (1mg/kg), in combination with medial doses of sour cherry pit extract (150 mg/kg). Then, to assess the anti-nociceptive effects of the extract, we used Writhing and Tail-flick tests.
FINDINGS: The results of the study showed that the extract significantly inhibited the number of contractions induced by injection of acetic acid. the Results of Tail-flick test showed that the delay time of tail removal after injection in all groups was significantly associated with latency of tail withdrawal before injection (P <0.05). The group which receives the extract with a dose of 250 (mg / kg body weight) showed more analgesic effects than other doses of the extract and the mean delay in this group was significantly higher than other doses (p <0.05).
 CONCLUSION: According to the present results, the alcoholic extract of sour cherry pit has analgesic effects which is dependent on dosages. Therefore, the presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.
Keywords: Rat, Cherry pit, PAIN
     
Type of Study: Research | Subject: Physiology
Received: 2017/11/17 | Accepted: 2018/07/19 | Published: 2018/08/3
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mahmoodi M, vazini H, shahidi S, ghiyayi H, notghi P. The analgesic effect of alcoholic extract of sour Cherry pit in male rat. Armaghane danesh. 2018; 23 (3)
URL: http://armaghanj.yums.ac.ir/article-1-2001-en.html


Volume 23, Issue 3 (8-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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