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:: Volume 18, Issue 6 (10-2013) ::
__Armaghane Danesh__ 2013, 18(6): 453-462 Back to browse issues page
Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition
A Divsalar 1, J Behroozi, AA Saboury, NN Poursasan
1- , divsalar@tmu.ac.ir
Abstract:   (3975 Views)
Abstract Background & aim: Diabetes is a common disease which is characterized by hyperglycemia and the increase of protein glycation. The aim of this study was to investigate the effect of aspirin-induced damage in human hemoglobin in diabetic glycation. Materials & Methods: In this study, hemoglobin extracted from the blood of healthy individuals was incubated in the presence and absence of glucose and aspirin for 5 weeks. The rate of haem glycotation was determined in different conditions by studding products of Heam degradation, sort-band shifting and febrile state. Data were analyzed using One-Way analysis of Variance and Tukey’s test. Results: In the presence of aspirin, the amount of glycation reduced 50%. Furthermore, studies using band-shift sorting and febrile status indicated significant reduce in the amount of protein glycation in the presence of Aspirin. Conclusions: Aspirin reduces extent of glycation when hemoglobin is incubated in the presence of glucose. Likely, aspirin exerts its effect by acetylating amine groups in proteins. Key words: Diabetes, Glycation, Hemoglobin, Aspirin
Keywords: Key words: Diabetes, Glycation, Hemoglobin, Aspirin
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Type of Study: Research | Subject: Special
Received: 2015/04/15 | Accepted: 2015/04/15 | Published: 2015/04/15
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Divsalar A, Behroozi J, Saboury A, Poursasan N. Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition. Armaghane danesh. 2013; 18 (6) :453-462
URL: http://armaghanj.yums.ac.ir/article-1-227-en.html

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Volume 18, Issue 6 (10-2013) Back to browse issues page
ارمغان دانش Armaghane danesh
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