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Preservative effects of Aspirin on Human Hemoglobin glycation in Diabetic Condition
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A Divsalar   1, J Behroozi , AA Saboury , NN Poursasan |
| 1- , divsalar@tmu.ac.ir |
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Abstract: (4829 Views) |
| Abstract
Background & aim: Diabetes is a common disease which is characterized by hyperglycemia and the increase of protein glycation. The aim of this study was to investigate the effect of aspirin-induced damage in human hemoglobin in diabetic glycation.
Materials & Methods: In this study, hemoglobin extracted from the blood of healthy individuals was incubated in the presence and absence of glucose and aspirin for 5 weeks. The rate of haem glycotation was determined in different conditions by studding products of Heam degradation, sort-band shifting and febrile state. Data were analyzed using One-Way analysis of Variance and Tukey’s test.
Results: In the presence of aspirin, the amount of glycation reduced 50%. Furthermore, studies using band-shift sorting and febrile status indicated significant reduce in the amount of protein glycation in the presence of Aspirin.
Conclusions: Aspirin reduces extent of glycation when hemoglobin is incubated in the presence of glucose. Likely, aspirin exerts its effect by acetylating amine groups in proteins.
Key words: Diabetes, Glycation, Hemoglobin, Aspirin |
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| Keywords: Key words: Diabetes, Glycation, Hemoglobin, Aspirin |
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Full-Text [PDF 897 kb]
(1404 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/15 | Accepted: 2015/04/15 | Published: 2015/04/15
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