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Efficacy of Desmopressin(Nasal Spray) and OxybutininCombination Therapy in theTreatment of Patients withPrimary Nocturnal Enuresisthat were Resistant to Singlethat were Resistant to Single
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SA Mehrabi Sisakht   , HR Ghaffarian Shirazi , SA Bagherineia |
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Abstract: (34970 Views) |
| ABSTRACT
Introduction & Objective: Enuresis is defined as involuntary
voiding. It is a socially disruptive and stressful condition which
affects around 15% of five years old children and up to 1% of
adults. Aim the aim of this study was to assess the efficacy of
desmopressin (nasal spray) and oxybutinin combination therapy in
treatment of patients with primary nocturnal enuresis that were
resistant to single drug therapy.
Materials &Methods : This study is a prospective clinical trial
conducted on patients aged 5-15 years old referred to urology
clinic due to nocturnal enuresis. After taking history , physical
examination , checking laboratory test , and ruling out the organic
causes patients were treated with vasopressin or imipramin or
oxybutinin at first. If no responses to this treatment was
observed after 3 weeks, then the patients were treated by
combination therapy ,giving desmopressin (10-20μg) and
oxybutinin 2.5-5 mg) at bed time for 4-6 months. 70 patients
were treated by combined therapy and then patients were followed
up evaluated for responses, relapses and side effects of this
drugs .
Results :The results demonstrate the efficacy of this treatment.
60 % of patients were responded completely, 34.3% partially
responded and no response was found in 57% of cases. 5.7% of
patients developed minor side effects with combination therapy.
Finally 44.3% of patients showed partial or complete relapse of
enuresis 1 month after treatment .
Conclusion : Based on these results , we can suggest that
children with nocturnal enuresis who are resistant to single drug
therapy, can be treated with this combination therapy .
Reduction of urinary output and thus lowering of bladder filling
by desmopressin , decreases the onset of inhibited bladder
contraction and enhances the activity of oxybutinin. However due
to cost and shortage of this drugs, we recommend this treatment
only for patients with no response to single drug therapy , or
other current therapies. |
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| Keywords: Enuresis, Desmopressin, Oxybutinin, Combination therapy |
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Full-Text [PDF 238 kb]
(2663 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/06/13 | Accepted: 2015/06/13 | Published: 2015/06/13
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