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Investigation the effect of Commiphora mukul on blood glucose and Serum lipid profile in diabetic rats
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Leila Shirazi1   , Iraj Salehi2 , Shirin Moradkhani 3 |
1- Faculty of Basic Sciences, Islamic Azad University, Hamadan Branch, Hamadan, Iran,
2- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Pharmacognosy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. |
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Abstract: (15895 Views) |
| Background & aim: The decrease of serum glucose level and lipids in diabetic patients is clinically significant. The purpose of this study was to determine the effect of Commiphora mukul extract on blood sugar and lipid profile in diabetic rats.
Methods: In the present experimental study, thirty-two male Wistar rats were randomly divided into four groups: control, control treated with the extract, diabetic and diabetic treated with the extract. Diabetes was induced by intraperitoneal injection of Streptozotocin. In an eight week period, the control group of normal saline and the control group and diabetic recipient extract of CM oleo gum blue resin was given by gavage. Treatment resumed eight weeks with onset of hyperglycemia. The control and diabetic control groups received normal saline orally. Extract treated control and extract treated diabetic groups received extract of Commiphora mukul gum (300 mg/kg P.O.) daily by gavage. At the end of this period, blood samples were collected from each rat and biochemical tests for investigation of glucose level and lipid profile was performed. One- way analysis of variance (ANOVA) statistical test and Post-hoc test Tukey’s were used for data analysis
Results: The study indicated that diabetes increases the serum levels of glucose, cholesterol, triglycerides, LDL and HDL. Administration of Commiphora mukul gum extract in diabetic groups significantly decreased the serum level of glucose, cholesterol(p<0.01) and triglyceride and LDL(p<0.001) and increased HDL(p<0.01).
Conclusion: Commiphora mukul gum extract may well improve undesirable effects of diabetes on serum level of glucose, cholesterol, triglyceride, LDL and HDL. |
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| Keywords: Diabetes, Commiphora mukul, glucose, lipid profile |
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Full-Text [PDF 145 kb]
(1612 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/02/27 | Accepted: 2015/02/27 | Published: 2015/02/27
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