Methods: In the present experimental study, 42 male Wistar rats weighing 200 ± 220gr were divided into 6 groups: (n=7) as follows: control group, positive control group (silymarin, 100 mg/kg body weight, gavaged), sham group (received olive oil at the rate of 0.25 ml), CCl4 group (received carbon tetrachloride at the rate of 2 ml/kg of body weight, at a ratio of 1:1 with olive oil, ip), Treatment group 1 (receives of carbon tetrachloride + palm  meristem  extract, 250 mg/kg), treatment 2 (receives of carbon tetrachloride + palm  meristem  extract, 500 mg/kg) and  treatment 3 (carbon tetrachloride + palm  meristem  extract, 750 mg/kg). After the experiments, blood samples were collected and blood serum were separated and the serum levels of MDA, GSH and GPx and liver enzymes were analyzed. The liver tissue sample was separated and placed and prepared for histological studies. Statistical data were analyzed using GraphPad Prism 8 software and analysis of variance, Tukey's post hoc, and Kruskal-Wallis tests. 

Results: The results indicated that carbon tetrachloride caused liver tissue necrosis in CCl4 group rats. The serum levels of AST, ALT and ALP enzymes in the CCl4 group increased compared to the control group (p<0.001). The serum levels of GSH and GPx in treatment groups increased significantly with CCL4 group (p<0.001). 

Conclusion: Due to its phenolic and antioxidant compounds, hydroethanolic extract of palm cheese was able to protect liver tissue from the destructive damage of carbon tetrachloride and bring serum levels of liver enzymes back to normal.