1. Williams R. Global Challenges in Liver Disease. Hepatology 2006; 44: 521-6.## [DOI:10.1002/hep.21347] [PMID]

2. Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology of liver inflammation, damage and repair. Journal of Physiology and Pharmacology: an official Journal of the Polish Physiological Society 2008; 59(Suppl 1): 107-17.##

3. Malek M, Nematbakhsh M. Renal ischemia/reperfusion injury; from pathophysiology to treatment. Journal of Renal Injury Prevention 2015; 4(2): 20-7.##

4. Sharma U, Pal D, Prasad R. Alkaline phosphatase: an overview. Indian Journal of Clinical Biochemistry 2014; 29(3): 269-78.## [DOI:10.1007/s12291-013-0408-y] [PMID] []

5. Okada M, Sogo A, Ohnishi N. Glycation reaction of aspartate aminotransferase by various carbohydrates in an in vitro system. The Journal of Nutritional Biochemistry 1994; 5(10): 485-9.## [DOI:10.1016/0955-2863(94)90027-2]

6. McGill M R. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J 2016; 15: 817-828.##

7. Volpe DA, Ellison CD, Parchment RE, Grieshaber CK, Faustino PJ. Effects of amitriptyline and fluoxetine upon the in vitro proliferation of tumor cell lines. J Exp Ther Oncol 2003; 3(4): 169-84.## [DOI:10.1046/j.1359-4117.2003.01091.x] [PMID]

8. Ahmed AR, Hombal SM. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. Journal of the American Academy of Dermatology 1984; 11(6): 1115-26.## [DOI:10.1016/S0190-9622(84)80193-0] [PMID]

9. Oyagbemi AA, Omobowale OT, Asenuga ER, Akinleye AS, Ogunsanwo RO, Saba AB. Cyclophosphamide-induced hepatotoxicity in wistar Rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical. International Journal of Preventive Medicine. 2016; 7:51. ## [DOI:10.4103/2008-7802.177898] [PMID] []

10. Cuce G, Çetinkaya S, Koc T, Esen HH, Limandal C, Balcı T, et al. Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats. Chemico-biological Interactions 2015; 232: 7-11.## [DOI:10.1016/j.cbi.2015.02.016] [PMID]

11. Temel Y, Kucukler S, Yıldırım S, Caglayan C, Kandemir FM. Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation and apoptosis. Naunyn-Schmiedeberg's Archives of Pharmacology 2020; 393(3): 325-37.## [DOI:10.1007/s00210-019-01741-z] [PMID]

12. Novikov A, Vallon V. Sodium glucose cotransporter 2 inhibition in the diabetic kidney. Curr Opin Nephrol Hypertens 2016; 25: 50-8.## [DOI:10.1097/MNH.0000000000000187] [PMID] []

13. Khamseh ME. Effect of empagliflozin on liver steatosis and fibrosis in patients with non-alcoholic fatty liver disease without diabetes: A randomized, double-blind, placebo-controlled trial. Adv Ther 2020; 37: 4697-708.## [DOI:10.1007/s12325-020-01498-5] [PMID] []

14. Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, et al. Anti-inflammatory effects of empagliflozin and gemigliptin on lps-stimulated macrophage via the IKK/NF- κ B, MKK7/JNK and JAK2/STAT1 signalling pathways. J Immunol Res 2021; 2021: 9944880. ## [DOI:10.1155/2021/9944880] [PMID] []

15. Li C, Zhang J, Xue M, Li X, Han F, Liu X, et al. SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart. Cardiovascular Diabetology 2019; 18: 1-3.## [DOI:10.1186/s12933-019-0816-2] [PMID] []

16. Doustimotlagh AH, Panahi Kokhdan E, Vakilpour H, Khalvati B, Jafari Barmak M, Sadeghi H and Asfaram A. Protective effect of Nasturtium officinale R . Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats. Mol Biol Rep 2020; 47(7): 5001-12.## [DOI:10.1007/s11033-020-05556-7] [PMID]

17. Marwan A ElBaset , Rana S Salem , Fairouz Ayman , Nadeen Ayman , Nooran Shaban , Sherif M Afifi ,et all. Effect of Empagliflozin on Thioacetamide-Induced Liver Injury in Rats: Role of AMPK/SIRT-1/HIF-1α Pathway in Halting Liver Fibrosis. Antioxidants 2022 Oct 30;11(11):2152. https://doi.org/10.3390/antiox11112152 [DOI:10.3390/antiox11112152.##] [PMID] []

18. Gungor H, Ekici M, Karatas O, Dik B. Protective effect of Allium Scorodoprasum L. ethanolic extract in cyclophosphamide- induced hepatotoxicity model in rats Short Title: Allium Scorodoprasum L. extract can be protective in hepatotoxicity. J Pharm Pharmacol 2023; 75(5): 625-34.## [DOI:10.1093/jpp/rgad002] [PMID]

19. Hamzeh M. Hosseinimehr SJ, Khalatbary AR, Mohammadi HR, Dashti A , Talebpour Amiri F. Atorvastatin mitigates cyclophosphamide-induced hepatotoxicity via suppression of oxidative stress and apoptosis in rat model. Res Pharm Sci 2018; 13(5): 440-9.## [DOI:10.4103/1735-5362.236837] [PMID] []

20. Cuce G, Çetinkaya S, Koc T, Hasan Esen H, Limandal C, Balcı T, et al. Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats. Chemico-Biological Interactions 2015; 232: 7-11.## [DOI:10.1016/j.cbi.2015.02.016] [PMID]

21. Sumida Y, Yoneda M, Tokushige K, Kawanaka M, Fujii H, Yoneda M. et al. Hepatoprotective effect of SGLT2 inhibitor on nonalcoholic fatty liver disease. Diab Res Open Access 2020; 2(S1): 17-25.## [DOI:10.36502/2020/droa.6159]

22. El-Kashef DH , Sewilam HM . Empagliflozin mitigates methotrexate-induced hepatotoxicity: Targeting ASK-1/JNK/Caspase-3 pathway. Int Immunopharmacol 2023; 114: 109494.## [DOI:10.1016/j.intimp.2022.109494] [PMID]

23. Simental Mendía M, Sanchez García A, Rodríguez Ramírez M, Simental Mendía L E. Effect of sodium-glucose co-transporter 2 inhibitors on hepatic parameters: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2021; 163: 105319. ## [DOI:10.1016/j.phrs.2020.105319] [PMID]

24. Amir Mohamed Abdelhamid, Ahmed Ramadan Elsheakh, Rania Ramadan Abdelaziz, Ghada Mohamed Suddek. Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice. Life Sci 2020; 256: 117908. ## [DOI:10.1016/j.lfs.2020.117908] [PMID]

25. Manar G. Helal. Empagliflozin attenuates cyclophosphamide-induced hepatotoxicity via targeting Nrf2/HO-1 signaling, oxidative stress, and inflammation. World J Pharm Sci 2019; 7(11): 49-59.##

26. Ramezani S, Javadi I, Panahi Kokhdan E, Omidifar N, Nikbakht J, Sadeghi H. et al. Protective and therapeutic effects of ethanolic extract of Nasturtium officinale (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats. Res Pharm Sci 2021; 16(1): 94-102.## [DOI:10.4103/1735-5362.305192] [PMID] []

27. Casanova NA , Simoniello MF, Lopez Nigro M M , Carballo M A. Modulator effect of watercress against cyclophosphamide-induced oxidative stress in mice. Medicina(B Aires) 2017; 77(3): 201-6.##

28. Mohammad FA , Ahmed OA , Majed HS , Ahmad JAA , Saeed A , Hina R. et al. Therapeutic Potential of Capsaicin against Cyclophosphamide-Induced Liver Damage. J Clin Med 2023; 12(3): 911.## [DOI:10.3390/jcm12030911] [PMID] []

29. Oyagbemi AA, Omobowale OT, Asenuga ER, Akinleye AS, Ogunsanwo RO, Saba AB. Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical. Int J Prev Med 2016; 7: 51. ## [DOI:10.4103/2008-7802.177898] [PMID] []