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:: Volume 27, Issue 5 (8-2022) ::
__Armaghane Danesh__ 2022, 27(5): 0-0 Back to browse issues page
Comparison of the in vitro susceptibility of isolated oral Candida species of uncontrolled diabetic patients to Nystatin and Fluconazole
Mahdieh Azizi lari1 , Samira Hajimaghsoodi 2, Abbasali Jafari1 , Mohammad Hasan RbassiAkhavan Ka1 , Maryam Dehghan1
1- Shahid Sadoughi University of Medical Science
2- Shahid Sadoughi University of Medical Science , shmaghsoodi@yahoo.com
Abstract:   (26 Views)
Background and Aim: Denture stomatitis is the most common opportunistic infection caused by candida in denture wearer’s palate, which is more common and severe among diabetic patients. Several studies have already been conducted to examine various drugs for treatment of candidiasis. Recently, some cases of drug resistance of none albicans Candida species to antifungal drugs have been reported. The aim of this study was to compare the in vitro susceptibility of isolated Candida species of uncontrolled diabetic patients against Nystatin and Fluconazole.
Materials and Methods: In this lab trial study, 43 patients with uncontrolled diabetes mellitus and denture stomatitis, referring to Yazd Diabetes Research Center and Clinics were screened and sample were collected from the palate using strile swabs. Then, samples were cultured, to determine the differential colony counts through the color difference between the colonies, and also MIC of Nystatin and Fluconazole by two different methods (Broth microdilution &Disk diffusion). Data were analyzed using SPSS23 and Kruskal-Wallis test.
Results: In this study, the most commonly isolated species were: Candida albicans (38/3%), followed by Candida tropicalis (14/9%), Candida krusei (10/6%), Candida glabrata (8/5%) and other species (27/7%). According to both methods, Candida albicans was the most sensitive to both Nystatin and Fluconazole. The most resistant species to Nystatin and Fluconazole were Candida glabrata and Candida Krusei respectively. In 100% concentration, sensitivity of candida species to Nystatin was significantly higher than Fluconazole, except for Candida albicans (p-value=0/05).
Conclusion: This study showed that Nystatin was better than Fluconazole for treatment of denture stomatitis in uncontrolled diabetic patients.
Keywords: candidiasis, antifungal, diabetes, disc diffusion, Candida albicans.
Type of Study: Research | Subject: Dentistry
Received: 2022/03/8 | Accepted: 2022/09/13 | Published: 2022/09/18
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azizi lari M, hajimaghsoodi S, jafari A, rbassiAkhavan Ka M H, dehghan M. Comparison of the in vitro susceptibility of isolated oral Candida species of uncontrolled diabetic patients to Nystatin and Fluconazole. ارمغان دانش. 2022; 27 (5)
URL: http://armaghanj.yums.ac.ir/article-1-3277-en.html

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Volume 27, Issue 5 (8-2022) Back to browse issues page
ارمغان دانش Armaghane Danesh
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