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The effect of eight weeks of aerobic training with Propolis on some mitochondrial biogenesis markers in cardiac tissue of ovariectomized diabetic rats
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F Hasanzadeh Dolatabadi1    , KH Jalali Dehkordi2 , F Taghian1 , SA Hoseini3 |
1- Department of Physical Education and Sport Sciences, Isfahan(Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2- Department of Physical Education and Sport Sciences, Isfahan(Khorasgan) Branch, Islamic Azad University, Isfahan, Iran , khosrojalali@gmail.com
3- Department of Physical Education and Sport Sciences, Marvdasht Branch, Islamic Azad University, Isfahan, Iran |
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Abstract: (1986 Views) |
Background and aims: Postmenopausal is associated with heart and metabolic disorders. Although the beneficial role of physical activity and antioxidants in human health has been reported; However, the interactive effects of Aerobic training (AT) and Propolis (Pr) on mitochondrial biogenesis in cardiac tissue is not well understood. The aim of this study was to investigate the effect of eight weeks of AT with Pr on AMP-activated protein kinases (AMPK) and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) in the heart of ovariectomized diabetic rats.
Methods: 30 ovariectomized diabetic (40 mg/kg .ip, Stroptozotocin) rats, aged 16-12 weeks and weight 250-220 g were divided in 5 groups; (1) Control ovariectomized diabetic (COD), (2) Sham (Sh), (3) Pr, (4) AT and (5) AT + Pr. Also, 6 healthy rats were divided in Healthy Control (HC) group. Groups 4 and 5 trained for eight weeks, five sessions per week with 55-75% VO2max; Groups 3 and 5 received 100 mg/kg/day of Pr. One-way analysis of variance and Tukey's post hoc test in GraphPad Prism 8.3.3 software were used to analyze the data (P≥0.05).
Results: AMPK and PGC1α in AT group were significantly higher than COD and Sh groups (P≥0.05); PGC1α gene expression in Pr group was significantly higher than Sh group (P≥0.05). Also, AMPK and PGC1α gene expression in AT + Pr group were significantly higher than COD and Sh groups (P≥0.05).
Conclusion: It seems that the AT and Pr have beneficial effect on mitochondrial biogenesis in cardiac tissue following estrogen deficiency and diabetes. Therefore, the Pr and AT is recommended in ovariectomized and diabetic models. |
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| Keywords: Exercise, Propolis, AMP-activated protein kinases, PGC1α, Heart, Ovariectomy, Diabetes Mellitus |
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Full-Text [PDF 1066 kb]
(579 Downloads)
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Type of Study: Research |
Subject:
Sport Physiology
Received: 2021/10/6 | Accepted: 2021/12/1 | Published: 2022/02/28
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