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:: Volume 27, Issue 2 (3-2022) ::
__Armaghane Danesh__ 2022, 27(2): 185-195 Back to browse issues page
The effect of aqueous alcoholic extract of Parsley leaf (Petroselinum crispum) on pituitary-thyroid hormones in adult male rats following lead acetate poisoning
Fatemeh Bastampour1 , Ebrahim Hosseini 2, Mehrdad Shariaty1 , Mokhtar Mokhtary1
1- Department of Biology, Kazeron Branch, Islamic Azad University, Kazeron, Iran
2- Department of Biology, Faculty of Sciences, Zand Institute of Higher Education, Shiraz, Iran , ebrahim.hossini@yahoo.com
Abstract:   (139 Views)
Background and Aim: Lead is a heavy metal that enters the body as an environmental contaminant through the gastrointestinal tract or respiratory tract. Due to the effects of this metal on the physiological activities of the body and the use of medicinal plants in the treatment of metabolic disorders, this study was performed to investigate the effect of parsley leaf extract(PLE) on the serum levels of thyroid hormones. Methods: This experimental study was performed on 48 adult male rats divided into 6 groups of 8, including control, control (solvent-treated) and 4 experimental groups treated with 200mg / kg lead acetate,200 mg / kg of PLE and treatment with lead acetate and doses of 100 and 200 mg / kg of parsley were divided simultaneously. All administrations were performed by gavage for 21 days. Finally, after anesthesia of mice and blood sampling from animal hearts, serum levels of T4, T3 and TSH hormones were measured by ELISA method. The results were analyzed using ANOVA and Tukey tests and the difference in data was considered significant at the level of P <0.05. Results: The results showed that serum T4 and T3 levels increased in animals receiving lead and TSH showed a significant decrease at the level of P <0.05, while in animals treated with lead and PLE decrease the levels of T4 and T3 hormones. And TSH increased significantly. Conclusion: The data of this study showed that the PLE can modulate the increase in thyroid hormones caused by lead poisoning.
Keywords: Lead, Parsley leaves, TSH, T3, T4
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Type of Study: Research | Subject: Physiology
Received: 2021/07/18 | Accepted: 2022/04/3 | Published: 2022/04/3
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Bastampour F, Hosseini E, Shariaty M, Mokhtary M. The effect of aqueous alcoholic extract of Parsley leaf (Petroselinum crispum) on pituitary-thyroid hormones in adult male rats following lead acetate poisoning. ارمغان دانش. 2022; 27 (2) :185-195
URL: http://armaghanj.yums.ac.ir/article-1-3121-en.html

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Volume 27, Issue 2 (3-2022) Back to browse issues page
ارمغان دانش Armaghane Danesh
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