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:: Volume 26, Issue 2 (4-2021) ::
__Armaghane Danesh__ 2021, 26(2): 0-0 Back to browse issues page
Recurrent vulvovaginal candidiasis correlation with Interleukin 19 Gene Polymorphisms (rs2243191 T/C and rs1028181-513T/C): A case-control study in the female population
Sara Iesakhani1 , Sirous Naeimi 2, Behrouz Naeimi1 , Bahram Ahmadi1
1- Islamic Azad University
2- Islamic Azad University , Naeimi801@yahoo.com
Abstract:   (132 Views)
Introduction and objective: Vaginal candidiasis infection is the second most common disease after bacterial vaginitis, affecting about 75% of women at least once in their lifetime. 46 to 75% of these infections are caused by Candida albicans species, Various factors, including genetic and immunology factors, plays an important role in this disease. interleukin 19 is an important cytokine in immune system and has several polymorphisms in the promoter region. In the present study, the frequency of a number of IL-19 gene polymorphisms in patients with recurrent vaginal candidiasis was investigated.
 Materials and Methods: This case-control study was performed on 100 patients with recurrent vaginal candidiasis and 110 healthy individuals during 2016-2019. Five mL blood was taken from each participant and transferred to a tube containing EDTA anticoagulant. Genomic DNA was isolated using a special kit; the PCR chain reaction was performed by ARMS method and the results were analyzed with SPSS version 19.
 
Results: The results of this study showed that there is no significant difference in frequency of GG, AG and AA genotypes in the position of both rs2243191 and rs1028181 IL-19 gene in both patients and the control group (P> 0.05). Also, there is no significant difference in frequency of both A and G alleles in the mentioned positions between patients and the control group (P> 0.05).
Conclusion: No significant relationship was observed between recurrent vaginal candidiasis and IL-19 gene polymorphisms (rs2243191 T / C and rs1028181-513T / C).
Keywords: Candidia albicans, Vaginal candidiasis, Polymorphisms, IL-19 gene
     
Type of Study: Research | Subject: Gynaecology
Received: 2021/02/1 | Accepted: 2021/05/8 | Published: 2021/05/8
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iesakhani S, Naeimi S, Naeimi B, Ahmadi B. Recurrent vulvovaginal candidiasis correlation with Interleukin 19 Gene Polymorphisms (rs2243191 T/C and rs1028181-513T/C): A case-control study in the female population. Armaghane danesh. 2021; 26 (2)
URL: http://armaghanj.yums.ac.ir/article-1-3029-en.html


Volume 26, Issue 2 (4-2021) Back to browse issues page
ارمغان دانش Armaghane danesh
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