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The Effect of Helicobacter pylori Colonization on Parietal Cells Alteration in Rat Stomach
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F Aeini   , MJ Rezaie 1, Y Motaharinia , MA Rezaee |
| 1- , rezaiemj@muk.ac.ir |
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Abstract: (11084 Views) |
| Background & Aim: Parietal cells have an important role in the production of stomach acid and function. Helicobacter pylori colonization in the stomach may affect the function of these cells. The aim of this study was to evaluate the effect of Helicobacter pylori colonization of rat stomach parietal cells.
Methods: In this study, 10 rats in two experimental and control groups were divided. Animals were fed by Helicobacter pylori or PBS in the experimental and control groups respectively for 20 weeks. Afterwards, bacterial colonization and parietal cells alterations were evaluated in the stomach tissue, using different staining methods. Furthermore, apoptosis in these cells were evaluated by TUNEL method.
Results: Helicobacter pylori colonization in rat stomach was confirmed. In addition, degradation and ultra-structural changes of parietal cells in the experimental group was determined after 20 weeks. TUNEL staining results were indicative of parietal cells apoptosis in the experimental group.
Conclusion: This study confirmed that Helicobacter pylori in 20 weeks duration causes degradation and structural changes in rat stomach parietal cells and cell death could be through apoptosis. |
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| Keywords: Helicobacter pylori, Parietal cell, Rat |
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Full-Text [DOC 426 kb]
(2556 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/26 | Accepted: 2015/04/26 | Published: 2015/04/26
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