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:: Volume 26, Issue 4 And ضمیمه 1 (9-2021) ::
__Armaghane Danesh__ 2021, 26(4 And ضمیمه 1): 0-0 Back to browse issues page
Evaluating the effect of aerobic training and Curcumin Nutritional supplements on the anxiety behavior and locomotor activity of female balb/c mice exposed to lead nitrate using the hole-board test
Maryam Amooei1 , Zohre Meshkati 2, Rozita Nasiri3, Amir Bahador Dakhili4
1- Faculty of Physical Education and Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
2- Faculty of Physical Education and Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran , zmeshkati@gmail.com
3- 3. Iran National Elite Foundation
4- shahid chamran Branch,Technical and Vocational University(TVU),Kerman,Iran.
Abstract:   (93 Views)
Introduction & Objective: Lead is one of the neurotoxic environmental pollutants that causes anxiety behaviors. The aim of this study was to investigate the effect of aerobic exercise and curcumin diet supplement on anxiety behavior and locomotor activity of lead nitrate-infected female Balb / c mice in the hole-board test.
Methods: A total of 42 mice of the Balb / c strain weighing 30-25 grams were purchased from Pasteur Institute of Iran. One week before the start of the study, mice experienced low-intensity aerobic exercise for 10 minutes (five sessions) for adaptation and familiarization.The mice  were  randomly divided into seven groups (6 mice in each group) including the healthy mouse (control group), the negative control group receiving the distilled water, the negative control group receiving the distilled water and the ethanol solvent, the positive control group receiving lead nitrate, the treatment group receiving lead nitrate and eight-week aerobic training, treatment group receiving lead nitrate and natural curcumin supplement, and the treatment group receiving lead nitrate, natural curcumin, and eight-week aerobic exercise. At the end of the study, Hole-bord test was performed to assess the animal's anxiety behavior and motor activity. For statistical analysis, one-way analysis of variance test was used for multiple comparisons and Toki follow-up test. The level of significance in the tests was considered to be 0.05 and the results were reported as a mean of standard deviation.
Results: The results showed that after the lead treatment, the number of head-dipping and the latency time decreased compared to the control group(P = 0.01), while the number of line crossing increased( Motor activity) (P = 0.001). Curcumin supplementation increased the number of times the head was sunk into the holes (P = 0.03), increased the latency (P = 0.02) and decreased the number of times the lines crossed (P = 0.01) compared to the lead nitrate group. Aerobic exercise increased the latency (P = 0.02) and decreased the locomotor activity compared to the lead nitrate group (P = 0.01), but no significant change was observed in the number of head dips into the plate holes. In addition, performing aerobic exercises simultaneously with curcumin injection caused more head immersion into the holes (P = 0.001), increased latency (P = 0.01) and decreased motor activity compared to the experimental groups (P = 0.01).
Conclusion:  In general, it can be concluded that exposure to lead nitrate causes anxiety behavior. Also, aerobic training and curcumin supplementation can moderate the anxious effects of lead nitrate treatment.
Conclusion:  In general, it can be concluded that exposure to lead nitrate causes anxiety behavior. Also
 aerobic training and natural curcumin supplementation can moderate the anxious effects of lead nitrate treatment.
Keywords: Anxiety, Lead, Aerobic training, Curcumin.
     
Type of Study: Research | Subject: Special
Received: 2020/06/26 | Accepted: 2020/11/1 | Published: 2021/09/6
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Amooei M, Meshkati Z, Nasiri R, Dakhili A B. Evaluating the effect of aerobic training and Curcumin Nutritional supplements on the anxiety behavior and locomotor activity of female balb/c mice exposed to lead nitrate using the hole-board test. Armaghane danesh. 2021; 26 (4)
URL: http://armaghanj.yums.ac.ir/article-1-2832-en.html


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Volume 26, Issue 4 And ضمیمه 1 (9-2021) Back to browse issues page
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