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Treatment of Vaginal Candidiasis by Ethanolic Extract of Propolis in Rabbit
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A Ownagh   , M Adibhesami 1 |
| 1- , masood.adibhesami@gmail.com |
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Abstract: (4187 Views) |
| Background & aim: Propolis is a resinous substance collected by honeybees from buds and leaves of trees and plants, possessing various biological properties. This study aimed to assess the anti-fungal activities of Ethanolic extract of Propolis (EEP) in an experimental infection of vaginal candidiasis.
Methods: In this study, twenty-four female rabbits were used for experimental infections. Animals were randomly divided into six equal groups: positive control group, negative control group, and four treatment groups. The four test groups were given doses of 125, 250, 500 and 1000 µg/ml of Propolis Ethanolic extract respectively while the positive control group received the standard Nystatin treatment and negative control group were given saline, locally, two times a day for 20 days. The data were analyzed, using descriptive statistics.
Results: Among all groups, the results showed that dose of 1000 µg/ml of EEP were the most effective dose in treatment of experimental vaginal candidiasis. Clinical signs of vaginal candidiasis were healed in Nystatin group after 9 days. No effect was recorded after 20 days treatment of infection for others doses of EEP that were used in this study.
Conclusion: It can be concluded that Ethanolic extract of Propolis in 1000 µg/ml concentration could treat experimental vaginal candidiasis in rabbits in a shorter time in comparison with standard nystatin treatment.. |
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| Keywords: Rabbit, vaginitis, Candida albicans, Propolis, Nystatin |
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Full-Text [PDF 556 kb]
(2079 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/19 | Accepted: 2015/04/19 | Published: 2015/04/19
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