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:: Volume 17, Issue 3 (8-2012) ::
__Armaghane Danesh__ 2012, 17(3): 233-242 Back to browse issues page
Treatment of Vaginal Candidiasis by Ethanolic Extract of Propolis in Rabbit
A Ownagh , M Adibhesami 1
1- , masood.adibhesami@gmail.com
Abstract:   (4039 Views)
Background & aim: Propolis is a resinous substance collected by honeybees from buds and leaves of trees and plants, possessing various biological properties. This study aimed to assess the anti-fungal activities of Ethanolic extract of Propolis (EEP) in an experimental infection of vaginal candidiasis. Methods: In this study, twenty-four female rabbits were used for experimental infections. Animals were randomly divided into six equal groups: positive control group, negative control group, and four treatment groups. The four test groups were given doses of 125, 250, 500 and 1000 µg/ml of Propolis Ethanolic extract respectively while the positive control group received the standard Nystatin treatment and negative control group were given saline, locally, two times a day for 20 days. The data were analyzed, using descriptive statistics. Results: Among all groups, the results showed that dose of 1000 µg/ml of EEP were the most effective dose in treatment of experimental vaginal candidiasis. Clinical signs of vaginal candidiasis were healed in Nystatin group after 9 days. No effect was recorded after 20 days treatment of infection for others doses of EEP that were used in this study. Conclusion: It can be concluded that Ethanolic extract of Propolis in 1000 µg/ml concentration could treat experimental vaginal candidiasis in rabbits in a shorter time in comparison with standard nystatin treatment..
Keywords: Rabbit, vaginitis, Candida albicans, Propolis, Nystatin
Full-Text [PDF 556 kb]   (1945 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/04/19 | Accepted: 2015/04/19 | Published: 2015/04/19
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Ownagh A, Adibhesami M. Treatment of Vaginal Candidiasis by Ethanolic Extract of Propolis in Rabbit. armaghanj 2012; 17 (3) :233-242
URL: http://armaghanj.yums.ac.ir/article-1-259-en.html


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Volume 17, Issue 3 (8-2012) Back to browse issues page
ارمغان دانش Armaghane Danesh
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