Background and aim: Non-alcoholic steatohepatitis is a part of broad spectrum of chronic non-alcoholic fatty liver disease. The aim of present study was to evaluate the effect of 12 weeks vitamin E supplementation and aerobic training on liver enzymes level of non-alcoholic steatohepatitis patients (NASH).  

Methods: In the present quasi-experimental study, 30 NASH patients, aged 25-50 years were participated, and divided into three groups of vitamin E (n=10), aerobic training (n=10) and combination (aerobic training plus vitamin E, n=10) randomly. Vitamin E Supplementation and aerobic training combination groups consumed 400 IU per day of Vitamin E Supplementation. Also in the group of aerobic exercise and combined, exercise program including the increasing activity of anaerobic (running on a treadmill with increasing intensity every two weeks 5%) was carried out three times a week for 12 weeks. Data evaluation were analyzed using t-test, ANOVA and Scheffe.

Results: A significant differences was observed  ALT (intra-group) of vitamin E (0001/0 = p) aerobic exercise (0001/0 = p) and combination (001/0 = p), respectively.There was a significant difference was seen among pre – post training in AST in supplementation(P=0.001), aerobic training(P=0.001) and combination (P=0.002) groups. But no significant difference in ALP level observed(P>0.05). In comparison among the groups, a significant differences was observed between groups ALP vitamin E, combination aerobic exercise but no significant difference was observed among the groups at the levels of ALT and AST.

Conclusion: The results of this study showed that vitamin E supplementation and aerobic training can improve non-alcoholic steatohepatitis Patients (NASH).