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:: Volume 20, Issue 5 (8-2015) ::
__Armaghane Danesh__ 2015, 20(5): 369-380 Back to browse issues page
Protective Effects of Lycopene and Ellagic Acid on Gonadal Tissue, Maternal Newborn Rats Induced by Cadmiumchloride
K Hoshmand Motlagh 1, M Jafari Barmak 2, A Dehghan Manshadi 3, A Vahdati 1, HR Zargar 4, R Mahmoudi 5
1- Biology Department, Islamic Azad University Fars Science and Research Branch, Fars, Iran
2- 2Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
4- 4Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University Of Medical Sciences, Ahvaz, Iran
5- Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract:   (2841 Views)
Background & aim: Cadmium is a toxin which reduces the ability of the reproduction in humans .Different antioxidants damaging effects of toxins are eliminated .The purpose of this study was to investigate the protective effects of lycopene and Ellagic acid induced by cadmium chloride on the gonadal tissue of newborn rats during pregnancy. Methods: In the present experimental study, 30 adult female Wistar rats (180-200 gr) were prepared and maintained in standard conditions. The female rats were used for mating with the male. After observation of vaginal plaque, pregnant rats were randomly divided into 5 groups of 6 rats. Group I (normal): They were given normal saline in 13 days during pregnancy. Group II (Control): Cadmium chloride (1.5 mg / kg/ IP) was injected and normal saline was given to them in 13 days of during pregnancy. Group III: Cadmium chloride (1.5 mg / kg/ IP) was injected and ellagic acid (10 mg/kg/orally) in 13 days were injected during pregnancy. Group IV: Cadmium chloride (1.5 mg / kg/ IP) was injected and copene acid (20 mg/kg/orally) was injected in 13 days of during pregnancy. Group V: Cadmium chloride (1.5 mg / kg/ IP) was injected and ellagic acid (10 mg/kg/orally) and lycopene acid (20 mg/kg/orally) were injected in 13 days during pregnancy. After postpartum, Neonatal rats were anesthetized with ether. Animals were dissected, then the testes and Ovaries were removed and transferred to 10% formalin solution. After tissue processing, tissue sections were prepared and H&E stained. Data were analyzed by SPSS software and ANOVA test. Results: Average number of Sertoli cells ,spermatogonia ,Leydig, and the number of seminiferous tube in control group were compared to other groups that were treated with lycopene - ellagic acid and ellagic acid had been reduced-proves to be significant(P <0.05). Average diameter of seminiferous tube in control group compared to other groups that are treated with lycopene - ellagic acid and ellagic acid had been reduced-proves but is not significant. Mean primordial follicle diameter and number of primordial of ovary tissue in control group compared to other groups that were treated with lycopene - ellagic acid and ellagic acid had been increased-proved to be significant(P <0.05). Conclusion: The results showed that the combined treatment of ellagic acid and lycopene-ellagic acid may have reduced the toxic effects of cadmium chloride and may have improved the process of replicating the sex cells.
Keywords: Cadmium Chloride, Lycopene, Ellagic acid, Neonatal Rat, Gonads
Full-Text [PDF 559 kb]   (689 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/07/5 | Accepted: 2015/07/5 | Published: 2015/07/5
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Hoshmand Motlagh K, Jafari Barmak M, Dehghan Manshadi A, Vahdati A, Zargar H, Mahmoudi R. Protective Effects of Lycopene and Ellagic Acid on Gonadal Tissue, Maternal Newborn Rats Induced by Cadmiumchloride. Armaghane danesh. 2015; 20 (5) :369-380
URL: http://armaghanj.yums.ac.ir/article-1-942-en.html


Volume 20, Issue 5 (8-2015) Back to browse issues page
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