|
A review on the Effect of the Antibiotic Mupirocin in the Treatment of Staphylococcus aureus Infections: the Mechanism of Antimicrobial Action, Antibiotic Resistance and its Eepidemiology
|
A Sharifi1   , M Moeindoost2 , R Dehbanipour2 |
1- Department of Microbiology, Yasuj University of Medical Sciences, Yasuj, Iran , asgharsharifi@yahoo.com
2- Department of Microbiology, Yasuj University of Medical Sciences, Yasuj, Iran |
|
|
Abstract: (839 Views) |
Background & aim: Mupirocin (MUP) is a natural drug derived from crotonic acid that was first isolated from Pseudomonas fluorescens by Fuller et al. This antibiotic has a different chemical structure and mechanism of action and is a combination of pseudomonic acid A-D. Its mechanism of action is to inhibit protein synthesis by binding to bacterial isoleucyl tRNA synthetase. This antibiotic is often used to treat skin and soft tissue infections caused by Staphylococcus aureus isolates. Therefore, the aim of the present study was to determine and investigate the effectiveness of the antibiotic mupirocin in the treatment of Staphylococcus aureus infections: its antimicrobial mechanism of action, antibiotic resistance, and epidemiology.
Methods: The present review study was conducted in 2023. Using reliable databases in English and Farsi, articles which studied the mechanism of action of mupirocin on methicillin-resistant Staphylococcus aureus (MRSA) and the synergistic effect of this antibiotic with other compounds, as well as its epidemiology, were reviewed.
Inclusion criteria: All experimental and non-experimental studies on the mechanism of action of mupirocin to inhibit colonization as well as the epidemiology of this antibiotic in different regions of the world were evaluated and included in the present study. A total of 70 studies were included in this review, in English and Farsi.
Results: Mupirocin has been used to inhibit colonization and prevent staphylococcal infections in various settings such as surgery, and the results of the present review study indicated the emergence of resistance to this antibiotic, especially among MRSA isolates in many The number of points in the world is increasing.
Conclusion: Given that the emergence of resistance to these antibiotics is increasing day by day, diagnostic tests, identification of carriers, national and organizational guidelines for infection control, as well as surveillance and education measures can be effective in reducing resistance to mupirocin in MRSA isolates.
|
|
| Keywords: Mupirocin, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Resistance, Clinical treatment |
|
|
Full-Text [PDF 622 kb]
(7 Downloads)
|
Type of Study: Review Article |
Subject:
Microbiology
Received: 2024/07/7 | Accepted: 2024/12/16 | Published: 2025/02/4
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Sharifi A, Moeindoost M, Dehbanipour R. A review on the Effect of the Antibiotic Mupirocin in the Treatment of Staphylococcus aureus Infections: the Mechanism of Antimicrobial Action, Antibiotic Resistance and its Eepidemiology. armaghanj 2025; 30 (1) :116-134 URL: http://armaghanj.yums.ac.ir/article-1-3652-en.html
|
