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Volume 30, Issue 1 (1-2025) |
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Objectives: Mupirocin (MUP) is a natural crotonic acid derivative drug, was first extracted from Pseudomonas fluorescens by Fuller et al.This antibiotic has a different mechanism of action and chemical structure and is a combination of pseudomonic acid A-D. Its mechanism of action, inhibits protein synthesis through binding to bacterial isoleucyl tRNA synthetase. This antibiotic is often used to treat skin and soft tissue infections caused by Staphylococcus aureus isolates. In addition, mupirocin is a drug of choice for nasal decolonization, control of outbreaks and prevention of recurring infections. Methods: In this review article, reliable English and Farsi databases including Google Scholar, Pubmed, Scopus, Magiran were searched and articles that studied the mechanism of action of mupirocin on methicillin-resistant Staphylococcus aureus (MRSA), and they had studied the consumption of this antibiotic, were investigated. Result: The results of this review study showed that the advent
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Asghar Sharifi   1, Mobina Moeindoost , Razieh Dehbani pur |
| 1- , asgharsharifi@yahoo.com |
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Abstract: (120 Views) |
Objectives: Mupirocin (MUP) is a natural crotonic acid derivative drug, was first extracted from Pseudomonas fluorescens by Fuller et al.This antibiotic has a different mechanism of action and chemical structure and is a combination of pseudomonic acid A-D. Its mechanism of action, inhibits protein synthesis through binding to bacterial isoleucyl tRNA synthetase. This antibiotic is often used to treat skin and soft tissue infections caused by Staphylococcus aureus isolates. In addition, mupirocin is a drug of choice for nasal decolonization, control of outbreaks and prevention of recurring infections.
Methods: In this review article, reliable English and Farsi databases including Google Scholar, Pubmed, Scopus, Magiran were searched and articles that studied the mechanism of action of mupirocin on methicillin-resistant Staphylococcus aureus (MRSA), and they had studied the consumption of this antibiotic, were investigated.
Result: The results of this review study showed that the advent of resistance to these antibiotic, especially among methicillin-resistant staphylococcus aureus isolates, is increasing in many parts of the world,This level of resistance is different in geographical areas due to the widespread use of mupirocin.
Conclusion: Due to, that the advent of resistance to these antibiotics is increasing day by day, therefore, diagnostic tests, carrier identification, national and organizational guidelines for infection control, as well as supervisory measures and education can be effective in reducing resistance to mupirocin in MRSA |
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| Keywords: Mupirocin, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, resistance, clinical treatment |
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Type of Study: Review Article |
Subject:
Microbiology
Received: 2024/07/7 | Accepted: 2024/12/16 | Published: 2025/02/4
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sharifi A, moeindoost M, dehbani pur R. Objectives: Mupirocin (MUP) is a natural crotonic acid derivative drug, was first extracted from Pseudomonas fluorescens by Fuller et al.This antibiotic has a different mechanism of action and chemical structure and is a combination of pseudomonic acid A-D. Its mechanism of action, inhibits protein synthesis through binding to bacterial isoleucyl tRNA synthetase. This antibiotic is often used to treat skin and soft tissue infections caused by Staphylococcus aureus isolates. In addition, mupirocin is a drug of choice for nasal decolonization, control of outbreaks and prevention of recurring infections. Methods: In this review article, reliable English and Farsi databases including Google Scholar, Pubmed, Scopus, Magiran were searched and articles that studied the mechanism of action of mupirocin on methicillin-resistant Staphylococcus aureus (MRSA), and they had studied the consumption of this antibiotic, were investigated. Result: The results of this review study showed that the advent. armaghanj 2025; 30 (1) URL: http://armaghanj.yums.ac.ir/article-1-3652-en.html
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