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Investigating the relationship between the use of antibiotic prophylaxis on changes in blood factors, mortality, incidence of infection and drug resistance in burn patients in Amirul Mominin Accident and Burn Hospital, Shiraz
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Abdolkhalegh Keshavarzi   1, Mojtaba Ghaedi2 , Amir Emami3 , Ali Najafi4 , Zahra Rahgozar5 , Mitra Zardosht4 , Majid Hamzehnejadi4 , Somayeh Rajabpoor4 , Mohammad Dehbozorgi4 |
1- department of general surgery, school of medicine , Shiraz university of medical sciences, Shiraz , Iran , iliakeshavarzi@yahoo.com
2- Department of surgery, Jahrom University of medical science, Jahrom, Iran
3- Department of Microbiology, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Department of medical education, Shiraz University of medical sciences, Shiraz, Iran |
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Abstract: (221 Views) |
Introduction: The use of antibiotic prophylaxis in the treatment of burns is a controversial issue. Many specialists start antibiotic treatment after the patient is admitted to prevent infection, while in most cases, antibiotic use is not necessary. The aim of this study was to determine the relationship between the use of antibiotic prophylaxis on mortality, infection and drug resistance in burn patients without sepsis symptoms admitted to Amir al-Momenin Burn Injury Hospital.
Methodology: This analytical-cross-sectional study was conducted in 1400-1401 at Amir al-Momenin Burn Injury Hospital. 2982 patients were included in the study. Patients' information, results of bacterial culture and antibiotic resistance of isolated isolates were extracted from burn patients' registry system and health information system. Statistical analysis was done with the help of SPSS-24 software, and with paired t-test, the level of statistical significance in all tests was considered P≤0.05.
Findings: Antibiotic resistance in hospitalized patients with prophylaxis treatment was 54.30%. The rate of mortality and re-hospitalization of patients in patients with no antibiotic prophylaxis was zero; In addition, the blood, liver and kidney factors of the patients were within the normal range. There was no significant difference between platelet levels, alkaline phosphatase serum level, alanine aminotransferase, blood urea nitrogen level and its ratio to creatinine (P≥0.05) on the first day of hospitalization and at the time of discharge. But there was a significant difference between the levels of white blood cells, neutrophils and albumin (P<0.001) in the first three days of hospitalization and the time of discharge.
Conclusion: The use of prophylactic antibiotics has no effect in the treatment of burn diseases without infection, and in order to reduce microbial resistance, it is better to avoid unnecessary use of antibiotics in burn areas.
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| Keywords: prophylactic antibiotics, infection, mortality, laboratory factors, burns |
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Type of Study: Research |
Subject:
Infectious Disease
Received: 2023/11/26 | Accepted: 2024/04/30 | Published: 2024/05/20
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Keshavarzi A, Ghaedi M, Emami A, Najafi A, rahgozar Z, Zardosht M, et al . Investigating the relationship between the use of antibiotic prophylaxis on changes in blood factors, mortality, incidence of infection and drug resistance in burn patients in Amirul Mominin Accident and Burn Hospital, Shiraz. armaghanj 2024; 29 (3) URL: http://armaghanj.yums.ac.ir/article-1-3564-en.html
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