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:: Volume 20, Issue 11 (2-2016) ::
__Armaghane Danesh__ 2016, 20(11): 972-984 Back to browse issues page
Study of antinociceptive effects of Pelargonium geraveolens L. leaves hydroethanolic extract in male mice
N Heydari1, N Mirazi 2
1- Islamic Azad University, Hamedan, Iran
2- Bu-Ali Sina University, Hamedan- Iran. , mirazi205@gmail.com
Abstract:   (3947 Views)

Running title: Anti nociceptive, Pelargonium graveolens Abstract: Introduction: Pain is a somatosensory sense that as an indicator to diagnoses for diseases . Pelargonium graveolens is known as a medicinal plant with use in traditional medicine. The aim of this study is to evaluate the analgesic effect of Pelargonium graveolens leaves extract (PGE) in male mice Material and Methods: In this experimental study, 42 male mice were divided in 6 groups (n=7). The control group(taking normal saline,0.25 ml, i.p), morphine group( 1mg/kg, i.p), treated groups with PGE at doses of 100, 200 and 600mg/kg and group induced with naloxone (0.1mg/kg, i.p) + 200mg/kg of PGE. In order to evaluate the analgesic effects of PGE the tail flick and writhing tests were used. The data for each test were compared with One-way ANOVA and Tukey's post test. Results: Our results showed that PGE (200 and 600 mg/kg) increased pain thershold compared with control group in writhing and tail flick test significantly (P<0.001). Conclusion: The PGE has anitinociceptive effects in male mice. This analgesic effect of Pelargonium graveolens extract probably related to its flavonoids composition which has effect on opioid system.

Keywords: Tail flick, Writhing, Pain, Pelargonium graveolens, Mice
Full-Text [PDF 346 kb]   (1156 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/08/12 | Accepted: 2015/12/17 | Published: 2016/01/23
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Heydari N, Mirazi N. Study of antinociceptive effects of Pelargonium geraveolens L. leaves hydroethanolic extract in male mice. Armaghane danesh. 2016; 20 (11) :972-984
URL: http://armaghanj.yums.ac.ir/article-1-1007-en.html

Volume 20, Issue 11 (2-2016) Back to browse issues page
ارمغان دانش Armaghane danesh
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