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Comparison of the Antioxidant Properties of Vitamins E, C and Copper in the Prevention of Molybdenum Toxicity in Rabbits
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H Gerayesh-Borazjanian   , A Rasooli , A Shahryari , H Najafzadehvarzi , M Nouri |
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Abstract: (4974 Views) |
| Abstract
Background & aim: Oxidative stress is defined as an imbalance between oxidants and reluctant in the individual or its cells. The aim of this study was to compare the effects of antioxidant vitamins E and C in prevention of the toxicity of copper and molybdenum in rabbits.
Methods: In this experimental study, 25 adult rabbits were randomly divided into 5 groups.
The first group (control group) received no medication The second group received 80 mg/Kg/day sodium molybdate orally until symptoms of toxicity, the third group received 4 mg/kg of copper sulfate orally with sodium molybdate, Group IV 150 mg/kg of vitamin E with sodium molybdate orally, and group V 20 mg/kg orally received vitamin C with sodium molybdate. Using the total antioxidant capacity parameters, malondialdehyde and ceruloplasmin levels in rabbit’s serum parameters levels of oxidative stress and antioxidant defense were obtained after a 35-day trial. The obtained data was analyzed using ANOVA and Turkey's test.
Results: The results of the present study indicated that molybdenum induced alopecia and depigmentation and molybdenum as a stress factor increased levels of malondialdehyde. So that the amount of malondialdehyde from 1.285 in the control group to 1.849 µM/L Molybdenum increased significantly. Although this indexes in the groups receiving vitamin E and C decreased significantly from 0.375 to 0.426 µM/L respectively. However, the total antioxidant capacity in any of the groups compared with the control group showed no change.
Conclusion: Molybdenum toxicity is involved in the pathogenesis of oxidative stress and antioxidant agents of vitamins E and C can reduce its toxic effects.
Key words: Antioxidant, Molybdenum, vitamin E, vitamin C, Copper, Rabbit |
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| Keywords: Key words: Antioxidant, Molybdenum, vitamin E, vitamin C, Copper, Rabbit |
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Full-Text [PDF 566 kb]
(1300 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/28 | Accepted: 2015/04/28 | Published: 2015/04/28
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