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:: Volume 20, Issue 10 (1-2016) ::
__Armaghane Danesh__ 2016, 20(10): 848-857 Back to browse issues page
Comparative effects of balm hydro alcoholic extract and diazepam on reducing anxiety of in mice
M Modaresi 1, M Basravi2, I Sajadia2
1- Department of Physiology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran , mehrdad_modaresi@hotmail.com
2- 2Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Abstract:   (4513 Views)

Background & aim: Anxiety is a normal feeling which is experienced in threatening situations and can affect neural system. Wide spread of anxiety forces many people to permanent use of anti-stress drugs especially benzodiazepines. This study was carried out to compare the effects of balm extract and diazepam on anxiety adjustment.

Methods: In this experimental study 70 female mice weighing approximately 25 to 30 g were studied in seven treatments groups including control, placebo, anxiety, diazepam, 50, 100, and 200 mg/kg of balm’s hydro-alcoholic extract. Drug and extract doses were injected IP. After receiving the last dose, anxiety was induced using dark box and was evaluated by an elevated plus-maze. In order to increase the activity, the animals were kept in a box with black walls for 5 minutes. Then, in order to evaluate the response of anxiety in elevated plus maze transferred and count the time spent in the open arms for 5 minutes (as an indicator of anxiety) were observed and recorded. Obtained data were analyzed using SPSS 11.5 software.

Results: The results of tests on the treatment showed that the hydro alcoholic extract in 200 mg/kg dose increased the time of presence in open arms significantly which shows anxiety reduction. Also, movement activities of mice were significantly higher in this dose in proportion to diazepam.

Conclusion: According to results, hydro alcoholic extract of balm in 200 mg/kg dose can be a suitable replacement for diazepam in reducing anxiety reflexes.

Keywords: Melissa officinalis, Anxiety, Diazepam, Mice
Full-Text [PDF 194 kb]   (1276 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/06/29 | Accepted: 2015/12/5 | Published: 2015/12/9
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Modaresi M, Basravi M, Sajadia I. Comparative effects of balm hydro alcoholic extract and diazepam on reducing anxiety of in mice. Armaghane danesh. 2016; 20 (10) :848-857
URL: http://armaghanj.yums.ac.ir/article-1-924-en.html

Volume 20, Issue 10 (1-2016) Back to browse issues page
ارمغان دانش Armaghane danesh
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