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:: Volume 19, Issue 10 (1-2015) ::
__Armaghane Danesh__ 2015, 19(10): 883-892 Back to browse issues page
Effects of sinapic acid on memory retention in adult male Wistar rats
Mahshid Nosrat1, Akram Eidi 1, Ali Haeri Rohani1
1- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract:   (2721 Views)
Background & aim: Sinapic acid is a phenylpropanoid compound and is widely distributed in the plant kingdom and is obtained from various sources such as rye, fruits and vegetables. This study concerned effects of sinapic acid on memory retention of passive avoidance learning in adult male Wistar rats. Methods: In this experimental study, 64 male Wistar rats were randomly allocated into 8 groups. Control animals were intact. Sham group received vehicle of sinapic acid (Tween 80, 10%). The experimental rats administrated with sinapic acid at doses 0.01, 0.03, 0.05, 0.1, 1 and 10 g/rat respectively. Sinapic acid and Tween 80 were injected intracerebroventricular and post-training. Twenty-four hours after training, memory retention was evaluated with passive avoidance learning. The step through latency and time in dark compartment was measured. The data were expressed as mean values ± SEM and tested, using analysis of one-way ANOVA test. Results: Our results showed that post-training administration of sinapic acid at doses 0.05, 0.1, 1, 10 and 10 g/rat increased significantly the time of step-through latency and decreased significantly the time of dark compartment as compared to sham group (p<0.05). Conclusion: Sinapic acid potentiated significantly memory retention process.
Keywords: Sinapic acid, Memory, Learning, Rat
Full-Text [PDF 203 kb]   (791 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/02/27 | Accepted: 2015/02/27 | Published: 2015/02/27
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Nosrat M, Eidi A, Haeri Rohani A. Effects of sinapic acid on memory retention in adult male Wistar rats. Armaghane danesh. 2015; 19 (10) :883-892
URL: http://armaghanj.yums.ac.ir/article-1-78-en.html

Volume 19, Issue 10 (1-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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