|
Comparison of the Effects of Adding Epinephrine, Midazolam and Midazolam and Neostigmine Mixture to Lidocaine in Patients Undergoing Transabdominal Resection of Prostate
|
MA Sahmedini   1, SH Bigiezadeh |
| 1- , sahmeddinima@yahoo.com |
|
|
Abstract: (5195 Views) |
| ABSTRACT:
Introduction & Objective: Preemptive treatment of perioperative and postoperative pain is one of the principle roles of anesthesiologists. Regional anesthesia following injection of anesthetic drug has fewer side effects than local or systemic anesthesia and induces longer analgesia with high quality. This research aimed to compare the effects of adding epinephrine, midazolam and midazolam and neostigmine mixture to lidocaine in patients undergoing transabdominal resection of prostate .
Materials & Methods: This is a double blind randomized clinical trial performed in Doctor Shareeati Hospital in Fasa. Ninethy candidate patients for elective transabdominal resection of prostate who were classified in class I and II of ASA were categorized randomly in 3 groups. In group one 100 mg lidocaine 5% plus 5 ųg epinephrine, in group two 100 mg lidocaine 5% plus 2mg midazolam and in group three 100 mg lidocaine 5% plus 2mg midazolam with 25 ųg Neostigmine was injected into subarachnoid space and then the duration of painlessness and side effects such as nausea, vomiting, respiratory and drowsiness intraoperation and 24 hour post operation were recorded.
Results: The duration of analgesia was 130.2 ±11.59 minutes in group one, 321.6±30.90 minutes in group two and 1417.8±53.34 minutes in group three. The incidence of nausea and vomiting in group one was 6.5%, in group two was 6% and in group three was 19.4%. The incidence of drowsiness and respiratory depression in all groups were zero.
Conclusion : With co-administration of multiple spinal drugs which act in different sites in pain pathway for reducing pain, we can co administrate 25 mg neostigmine with 2mg midazolam and spinal lidocaine in order to maintain analgesia for 24 hours in patients. The most likely side effects were nausea and vomiting which could be controlled with antiemetic drugs. |
|
| Keywords: KEYWORDS:Midazolam, Neostigmine, Spinal Anesthesia |
|
|
Full-Text [PDF 178 kb]
(1023 Downloads)
|
Type of Study: Research |
Subject:
Special
Received: 2015/06/6 | Accepted: 2015/06/6 | Published: 2015/06/6
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
