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:: Volume 21, Issue 2 (5-2016) ::
__Armaghane Danesh__ 2016, 21(2): 114-122 Back to browse issues page
Protective effect of para aminopropiophenone on the testosterone and gonadotropin hormones changes upon gamma ray radiation in adult male rats
B Shojaei1, E Samani Jahromi2, S Zolghadri Jahromi 3
1- Department of Biophysics, Islamic Azad University, Jahrom Branch, Iran,
2- Young Researchers and Elit Club,
3- Department of Biophysics, Islamic Azad University, Jahrom Branch, Iran, , Z.Jahromi@ibb.ut.ac.ir
Abstract:   (2980 Views)

Introduction: In the recent decades, many researches have been conducted to prevent destructive effects of gamma-ray on the body tissues. One of these researches is the use of radio-protector before radiation. In this study, we examine para-amino propinophenone (PAPP) effects, as a radio-protector, on the variations of Gonadotropin and testosterone.

Materials and Method:In this experimental study, 70 adult male rats were studied. They were randomly divided into 10 septet groups. Control group received food and water; and no more experimental material was given or fed. Sham group receivedsolvent(ethanol 96%). Groups3,4 and 5 received10, 20, 40 mg/ kg of PAPP were injected. Group 6 was influenced by gamma-ray (2greys). Group 7 were given 1ml ofethanol and after a half an hour were influenced bygamma-ray (2greys).Groups8, 9 and 10 received 10, 20, 40 mg / kg of PAPP respectivelyafter a half an hour were influenced by gamma-ray (2greys).All injections continued for 3 days.All groups were bled to measure their testosterone, FHS and LH hormones.Statistical analysis carried out by SPSS 19 software.

Results: The findings show that in the groups treated by gamma-ray, the amount of testosterone, FHS and LH hormones were reduced significantly compared with control group (P≤ 0.05). In the groups treated by para-amino Propiophenone (PAPP) and gamma-ray (from low to high concentrations), the level of testosterone, FHS and LH hormones increased gradually so that in maximum level, the hormone level reached to control level.

Conclusion: PAPP reduced the damages caused by gamma-ray on the amount of testosterone, FHS and LH hormones. Its protective effect is dosage-dependent. It seems that PAPP protects cells and tissues from destructive effects of free radicals caused by gamma-rays, through hypoxia.

Keywords: gamma-ray, para-aminopropinophenone, testosterone, FHS, LH
Full-Text [PDF 444 kb]   (1010 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/05/18 | Accepted: 2016/04/23 | Published: 2016/05/9
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Shojaei B, Samani Jahromi E, Zolghadri Jahromi S. Protective effect of para aminopropiophenone on the testosterone and gonadotropin hormones changes upon gamma ray radiation in adult male rats. Armaghane danesh. 2016; 21 (2) :114-122
URL: http://armaghanj.yums.ac.ir/article-1-548-en.html


Volume 21, Issue 2 (5-2016) Back to browse issues page
ارمغان دانش Armaghane danesh
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