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:: Volume 14, Issue 1 (4-2009) ::
__Armaghane Danesh__ 2009, 14(1): 1-11 Back to browse issues page
Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache
H Khani 1, M Abedini , A Zarvani , A Azadmarzabadi , A Roshanbakhash , R Roshanbakhash , A Ghorbani
1- , dr.h.khani@gmail.com
Abstract:   (4411 Views)
ABSTRACT Introduction & objective: Migraine is the most common cause of headache. The aim of the present study was to evaluate the effects of topiramate (TPM) in the prevention of drug-resistant migraine headache. Materials & Methods: This is a double-blind clinical trial conducted on 70 patients between ages 15 to 45 years referred to the Bu Ali Sina Hospital in Sari with a history of migraine attacks based on International Headache Society criteria for a period of more than one years with a minimum incidence of 1 to 6 attacks per month. The drug rate performance was assessed by response rate to treatment, mean changes in the number and severity of migraine attacks compared with the placebo group for 3 months. Collected data were analyzed using analysis of variance (ANOVA), Newman-Keuls and Spearman’s Coefficient Rank Correlation as the post hoc tests. GRAPHPAD software was used for analysis of the data. Results: 66 of 70 patients completed the study. The mean age of the patients was 30.33±7.9 years. A significant reduction in the severity and frequency of migraine attacks was seen in all months (P < 0.0001) for topiramate treated group in compare to placebo group. Responder rate for patients treated with TPM was significantly higher than placebo group (63.6%, P<0.0001) in the 3rd month of the treatment Side effects of treatment were transient and well tolerated. Conclusion: Low dose of TPM showed significant efficacy in prevention of migraine attacks within the first, second, and third month of treatment. Low dose of TPM seems to be a good therapeutic option for the patients with refractory migraine.
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Type of Study: Research | Subject: Special
Received: 2015/05/17 | Accepted: 2015/05/17 | Published: 2015/05/17
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Khani H, Abedini M, Zarvani A, Azadmarzabadi A, Roshanbakhash A, Roshanbakhash R et al . Effects of Topiramate in the Prevention of Drug Resistant Migraine Headache . Armaghane danesh. 2009; 14 (1) :1-11
URL: http://armaghanj.yums.ac.ir/article-1-540-en.html


Volume 14, Issue 1 (4-2009) Back to browse issues page
ارمغان دانش Armaghane danesh
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