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Effect of Pistacia Vera Oil on Pituitary Gonad Axis and Histological Testis Changes in Adult Male Rats
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F Porhemmat   1, M Shariati , L Sepehrara |
| 1- , : fereshtehporhemmat@gmail.com |
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Abstract: (3977 Views) |
| Abstract
Background & aim: Pistachio oil contains the chemical compounds such as saturated and unsaturated fatty acids. Saturated fatty acids can inhibit 5-α- reductase enzyme and unsaturated fatty acids increase cholesterol levels in the body. The aim of the present study was to determine the effects of pistachio oil on adult male rats’ reproductive status.
Methods: In the present experimental study, 40 male Wistar rat were divided into five groups of eight. The control group received water and standard food the sham group received an equal of distilled water as a solvent and the experimental groups receiving 1, 2 and 4 ml/kg of pistachio oil for a period of 28 days orally. At the end of the 28th day, blood samples and preparation of tissue sections were taken from the rats. The results were analyzed by Excel, One- way analysis variance, and t- test.
Results: The results of hormonal assays revealed that the pistachio Vera oil at 2 and 4 ml/kg, had a significant increase in testosterone levels (P <0.05) compared to the control and sham groups. Histopathological analysis showed that the sperm density in seminiferous tubules of the testis in experimental groups increased significantly (P <0.05).
Conclusions: The pistachio Vera oil increased testosterone and tubular sperm density, possibly related with compounds such as palmitic and myrystic acids as the inhibitor of 5 - alpha - reductases and increased biosynthesis of 17 - beta hydroxysteroid dehydrogenase.
Key words: Pistachio Vera oil, Testis, Gonadotropin, Testosterone, Rat |
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| Keywords: Key words: Pistachio Vera oil, Testis, Gonadotropin, Testosterone, Rat |
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Full-Text [PDF 706 kb]
(1031 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/05/5 | Accepted: 2015/05/5 | Published: 2015/05/5
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