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Effects of Antioxidants Supplemment, Astaxanthin, Vitamin E, C, in Rat Fed a High-Fat Diet
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AA Vahidinia   , R Shakerhossini 1, H Mahjub |
| 1- , rshakerhosseini@yahoo.com |
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Abstract: (4195 Views) |
| Introduction & Objective: obesity is independently associated with increased oxidative stress in men and women. Natural antioxidants showed substantial antioxidative and anti-inflammatory activities in vivo. In this study, we examined the preventive effect of antioxidants supplement and/or restricted diet on the development of obesity induced by feeding a high-fat (HF) diet.
Materials & Methods: The present study was conducted at Hamadan University of Medical Sciences in 2009. Forty-eight male Wistar rats were randomly assigned to HF purified diet (61% kcal from fat) ad libitum, HF restricted (30%), HF supplemented with astaxanthin, vitamin E and C (HFS), HFS restricted (30%) for 12 weeks. Daily food intake and weekly body weight gain were measured. The collected data were analyzed by the SPSS software using Colmogroph- Smirnov, One-Way ANOVA, and Two-Way ANOVA.
Results: Dietary antioxidants suppressed body weight gain in the HF-diet ad libitum (-9.8%), and in HF restricted diet (-18.14%). Energy intake was not significant in HF with HFS (58.8 and 58.6 kcal/rat/d, respectively) and in HF restricted with HFS restricted (41.7 and 41.6 kcal/rat/d, respectively).
Conclusion: results of this study suggest that antioxidants supplement might be of value in reducing the likelihood of obesity in rats fed with high-fat diets, especially when accompanying with restricted diets. |
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| Keywords: Antioxidant, High-Fat Diet, Obesity |
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Full-Text [PDF 187 kb]
(1291 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/05/4 | Accepted: 2015/05/4 | Published: 2015/05/4
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