[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 19, Issue 2 (5-2014) ::
__Armaghane Danesh__ 2014, 19(2): 100-110 Back to browse issues page
Evaluation of mexiletine effect on duration of sensory and motor block in spinal anesthesia with lidocaine
M Haghbin, MR Askarzadeh, M Sharifzadeh 1, M Shabani
1- , Mahdieh.sharifzade@yahoo.com
Abstract:   (4747 Views)
Abstract Background & aim: The methods to increase duration of spinal anesthesia is always noticed.,the aim of this study was to investigate the effect of mexiletine on duration of sensory and motor block in spinal anesthesia. Methods: In a clinical trial study 60 patients with age 18-50, ASA 1,2 who were scheduled for lower limb elective surgery at Shahid Bahonar hospital were enrolled. They were randomally assigned in two groups of control and intervention. Intervention group received oral mexiletine 200 mg 2hours before operation and control group received placebo.Spinal anesthesia was carried out with lidocaine /5 (100mg) in L2-L3 or L3-L4 space by the same method in two groups. Pulse rate,Pulse oximetry and mean arterial blood pressure were recorded in two groups every 5-10 minutes.Also the duration of sensory and motor block was recorded. The results were analyzed with Student t-test,Chi square and Mann-Whitney. Results:The onset of sensory and motor block was significantly faster in intervention group.(P<0/01) The duration of sensory and motor block was significantly more in intervention group than control.(P<0/001) The pulse rate in intervention group were signifigantly less than control group in 0,5,10,60,75 minutes after spinal injection. (P<0/05) Conclusion: Mexiletine is effective in increasing duration of sensory and motor block in spinal anesthesia with lidocaine and also increases the onset of both sensory and motor block with lidocaine. Key Words: Mexiletine, Sensory and motor block, Spinal anesthesia, Lidocaine
Keywords: Key Words: Mexiletine, Sensory and motor block, Spinal anesthesia, Lidocaine
Full-Text [PDF 196 kb]   (705 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/05/4 | Accepted: 2015/05/4 | Published: 2015/05/4
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haghbin M, Askarzadeh M, Sharifzadeh M, Shabani M. Evaluation of mexiletine effect on duration of sensory and motor block in spinal anesthesia with lidocaine. Armaghane danesh. 2014; 19 (2) :100-110
URL: http://armaghanj.yums.ac.ir/article-1-434-en.html


Volume 19, Issue 2 (5-2014) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4162