Background and Objective: Today, due to changes in lifestyle and environmental pollution, allergic diseases such as allergic asthma or allergic rhinitis are on the rise. Allergic asthma is a chronic, long-term inflammatory disorder of the respiratory tract that affects all ages. Despite appropriate treatment options, allergic asthma can lead to death if left uncontrolled. This study aimed to investigate the types of allergens effective in allergic asthma, with an emphasis on house dust mites and saprophytic fungi. Methods: This research was a review study. Based on the keywords including; allergy, allergic asthma, allergen, house dust mites, saprophytic fungi, it was conducted in scientific databases and search engines. The most important sources were selected and reviewed according to the title and purpose of the study. Findings: House dust mites and saprophytic fungi are considered as one of the most common causes of allergic asthma in humans. Because the highest percentage of allergens in allergic asthma patients was related to house dust mites, about 88%, and saprophytic fungi, about 83%. In general, indoor or closed space allergens include house dust mites, cockroaches, pet dander, saprophytic fungi or molds, and outdoor or outdoor allergens include weed, grass, and tree pollen. Identifying the geographical and seasonal distribution of allergens is of great help in the diagnosis and treatment of allergic diseases, and provides the possibility of immunotherapy conditions and reduces treatment costs. Conclusion: By reducing humidity to less than 50 percent, washing sheets with hot water, using anti-mite mattress and pillow covers, adequate ventilation and lighting in homes, removing saprophytic fungi, and specific immunotherapy against mites, allergic asthma can be prevented, and avoiding allergens in the living environment is preferable to common treatments.