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:: Volume 28, Issue 1 (3-2023) ::
__Armaghane Danesh__ 2023, 28(1): 74-86 Back to browse issues page
Examination and Sampling of Chorionic Villi for the Diagnosis of Beta-Thalassemia Major in the First Trimester of Pregnancy in Southwestern Iran
E Shams1 , M AllahDadian2 , Z Yadegari Baharanchi3 , M Harfsheno 4
1- Behbahan Faculty of Medical Sciences, Behbahan, Iran
2- Department of Midwifery, Flavarjan branch,Islamic Azad University, Isfahan, Iran
3- Department of Biology, Noordanesh Institute of Higher Education, Mimeh, Isfahan, Iran,
4- Department of Nursing and Midwifery, Behbahan Branch, Islamic Azad University, Behbahan, Iran. , moj.harfsheno@gmail.com
Abstract:   (1028 Views)
Background & aim: Beta thalassemia is one of the most common hereditary diseases in Iran. The birth of a child with thalassemia causes many social and economic problems for parents and the health care system. Nowadays, prenatal screening programs to detect beta thalassemia have received much attention in the country. The aim of the present study was the determination and sampling of chorionic villi for the diagnosis of beta-thalassemia major in the first trimester of pregnancy in south-western Iran.

Methods: The present descriptive-prospective and practical study was conducted in 2021 on couples suffering from thalassemia minor and referred to the Narges Genetics Laboratory in Ahwaz, Iran. For preventive measures, blood samples were taken from volunteers. At that point, the couples who had HbA2 above 3.5 and were in the 10th to 13th week of pregnancy continued the treatment by performing chorionic villus sampling in order to evaluate the health of the fetus. Chorionic villus sampling was performed under local anesthesia with a needle from the abdominal area of pregnant women, and about 5-10 cc of placental trophoblast villi were collected. The collected data were analyzed using t-test and chi-square statistical tests.

Results: A total of 91 pregnant women underwent chorionic villus sampling. Thirty-eight individuals (41.8%) had thalassemia minor, 25 individuals (27.5%) had thalassemia major, the familial relationship between couples was also examined, and there was no significant association between the familial relationship and occurrence of thalassemia major. 20 people (30%) had a child with thalassemia major and 60 people (66%) had a child with thalassemia minor. Fetuses with thalassemia major in mothers with blood type A+, 38 subjects (42%) and O+ 35 subjects (38.4%), the prevalence of thalassemia major was higher in the Fars subjects, the highest in 39 subjects (42.8%), and the lowest was the Kurdish people with one person (1 percent).

Conclusion: The technique of chorionic villus sampling is an accurate method with no significant risk to both mother and fetus. This method can be used to diagnose beta thalassemia before birth.

 
Keywords: Chorionic villus sampling, Prenatal diagnosis, Beta thalassemia
Full-Text [PDF 316 kb]   (363 Downloads)    
Type of Study: Research | Subject: Gynaecology
Received: 2022/07/26 | Accepted: 2022/12/17 | Published: 2023/01/4
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Shams E, AllahDadian M, Yadegari Baharanchi Z, Harfsheno M. Examination and Sampling of Chorionic Villi for the Diagnosis of Beta-Thalassemia Major in the First Trimester of Pregnancy in Southwestern Iran. armaghanj 2023; 28 (1) :74-86
URL: http://armaghanj.yums.ac.ir/article-1-3344-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 28, Issue 1 (3-2023) Back to browse issues page
ارمغان دانش Armaghane Danesh
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