[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 4 (10-2011) ::
__Armaghane Danesh__ 2011, 16(4): 332-340 Back to browse issues page
The Effect of Catechin on Fungal Biofilm Formation of Standard Susceptible and Resistant Strains of Candida albicans
F Haghighi, SH Roudbar Mohammadi1, Z Farhadi
1- , sh.mohammadi@madares.ac.ir
Abstract:   (3437 Views)
Background & Aim: Candida albicans is the most common cause of fungal infections which is increasing all over the world. Finding new methods or agents for control of these fungal infections is necessary. The aim of this study was to evaluate the antifungal activity of Catechin against standard strain of C.albicans. Methods: This experimental study was conducted at Tarbiat Modares University of Medical Sciences in 2010. Serial dilutions of Catechin solution were prepared in 96 well micro plates. Minimum Inhibitory Concentration (MIC) was assessed by Microdilution broth technique. Biofilms of C. albicans were developed on flat-bottomed 96-well microtiter plates and the antifungal effect of Catechin was evaluated. Data were analyzed using t-test statistical method. Results: MIC50 of 5.77 µg/ml, MIC90 of 8.33 µg/ml and MFC of 9.47 µg/ml were found for Catechin. Biofilm inhibitory concentration of Catechin and fluconazole for susceptible strain of C. albicans was19.35, 4 µg/ml and for resistant strain was 23.53, 8 µg/ml respectively. Conclusion: Catechin had suitable antifungal effect against C.albicans biofilms in comparison with fluconazole. It seems that this herbal agent can be used for the elimination of Candida.
Keywords: Biofilm, Candida, Catechin
Full-Text [PDF 798 kb]   (1341 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/04/27 | Accepted: 2015/04/27 | Published: 2015/04/27
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haghighi F, Roudbar Mohammadi S, Farhadi Z. The Effect of Catechin on Fungal Biofilm Formation of Standard Susceptible and Resistant Strains of Candida albicans. ارمغان دانش. 2011; 16 (4) :332-340
URL: http://armaghanj.yums.ac.ir/article-1-326-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 4 (10-2011) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4422