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The Effect of Aerobic Training on Expression of Indices of Myocardial Hypertrophy and Atrophy in Rats
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H Afshar1    , A Abdi2 , A Barari1 , MA Azarbayjani3 |
1- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran,
2- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran, , a.abdi58@gmail.com
3- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. |
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Abstract: (3138 Views) |
Background & aim: Protein synthesis and degradation are dynamically regulated processes that to control the accretion or loss of muscle mass. However, the mechanisms responsible exercise-induced heart hypertrophy remains elusive. The aim of the present study was to investigate the effect of aerobic training on expression of some indices of myocardial hypertrophy and atrophy in male rats.
Methods: In this experimental study conducted in 2018, 16 wistar male rats 10 weeks old with 299.74±19.32 g weight were randomly classified into control and training groups. Training group performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks. At the end of six week’s heart tissue samples were collected and used for determination of gene expression (AMP-activated protein kinase, fork head Box O3, Muscle atrophy F-box and Muscle RING finger 1). Data were analyzed using Independent t test at p<0.05.
Result: Six weeks aerobic training significant increased the heart AMP-activated protein kinase in rats (p=0.014). Also heart fork head Box O3 (p=0.022), Muscle atrophy F-box (p=0.032) and Muscle RING finger 1 (p=0.028) was significantly decrease than training group.
Conclusion: Aerobic exercise improved the heart structure by improving the parameters that affect cardiac size, possibly improving cardiac function.
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| Keywords: Aerobic Exercise, AMP-Activated Protein Kinase, fork head Box O3, Muscle Atrophy Fbox and Muscle RING finger 1 |
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Full-Text [PDF 1417 kb]
(651 Downloads)
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Type of Study: Research |
Subject:
Sport Physiology
Received: 2020/01/19 | Accepted: 2020/06/30 | Published: 2021/03/2
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