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:: Volume 25, Issue 1 (2-2021) ::
__Armaghane Danesh__ 2021, 25(1): 0-0 Back to browse issues page
Protective role of remote ischemic per-conditioning in acute renal injury induced by ischemia reperfusion via TLR-4 and TNF-α signaling pathway in rats
Firuzeh Gholampur Dr1, Jamshid Roozbeh Professor2, Sahar Janfeshan Dr3, Leila Malekmakan Dr1, Khojaste Rahimi Jaberi Miss2, Zeinab Karimi Dr 4
1- Shiraz university
2- Shiraz university of medical sciences
3- Islamic Azad University
4- Shiraz University of Medical Sciences , zkarimi@sums.ac.ir
Abstract:   (813 Views)
sIntroduction: Acute kidney injury (AKI) induced by ischemia-reperfusion (I / R) of the kidney as an inflammatory process in which multiple inflammatory factors are involved. Recently, one of the modalities of inflammation in AKI is Remote Ischemic Per-Conditioning (RIPerC). Materials and Methods: In this study, bilateral renal artery and vein occlusion were done for 45 minute and reperfusion and 24 h. The RIPerC model consisted of four five-minute cycles (two minutes of left femoral artery occlusion and three minutes of reperfusion) performed at the onset of renal ischemia. Rats were divided into control, I / R and RIPerC groups. At the end of the reperfusion period, urine, blood and kidney tissue samples were collected for functional, structural and molecular analysis. Results: Ischemia-reperfusion caused tissue damage and consequently renal dysfunction, which was shown by decreasing creatinine clearance and increasing relative excretion of sodium. In addition, in the I / R group, TLR-4 and TNF-α in mRNA levels were increased, whereas RIPerC simultaneously with I / R improved kidney structure and function and decreased TLR-4 and TNF-α expression levels. Conclusion: RIPerC protected the kidney against ischemia-reperfusion-induced kidney injury and probably this protective TEMPeffect was exerted by inhibition of TLR-4 signaling pathway in the kidney.
Keywords: Ischemia-renal reperfusion, Remote ischemic per conditioning, Toll like receptor-4, TNF-α, kidney inflammation, creatinine clearance
     
Type of Study: Research | Subject: Physiology
Received: 2019/08/28 | Accepted: 2020/02/17 | Published: 2020/03/4
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Gholampur F, roozbeh J, janfeshan S, Malekmakan L, Rahimi Jaberi K, Karimi Z. Protective role of remote ischemic per-conditioning in acute renal injury induced by ischemia reperfusion via TLR-4 and TNF-α signaling pathway in rats. Armaghane danesh. 2021; 25 (1)
URL: http://armaghanj.yums.ac.ir/article-1-2607-en.html


Volume 25, Issue 1 (2-2021) Back to browse issues page
ارمغان دانش Armaghane danesh
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