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:: Volume 25, Issue 2 (4-2020) ::
__Armaghane Danesh__ 2020, 25(2): 0-0 Back to browse issues page
Association of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis
Amin Karimpour, Amirhosein Mazare, Shiva Hadianpour, Masoumeh Molla Agha Zarandi, Behnam Alipoor 1
1- , behnam.alipour@yums.ac.ir
Abstract:   (1024 Views)
Background and Aim:
Several investigations have evaluated the association of miR-146a rs2910164 and miR-27a rs895819 single-nucleotide polymorphisms with susceptibility to type 2 diabetes (T2D). However, the findings are conflicting and inconclusive. Therefore, this meta-analysis performed to investigate the association between these polymorphisms and T2D risk.
Methods:
Studies were identified via a systematic search of the PubMed, Google scholar, Scopus and Sciencedirect databases up to June 2, 2019. A total of 2069 cases and 1947 controls for miR-146a rs2910164 and 1090 T2D and 966 non-diabetic subjects for miR-27a rs895819 were included in this meta-analysis by pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
Our results indicated that there were no significant association between miR-146a rs2910164 and miR-27a rs895819 variants and the T2D risk (P>0.05).
Conclusion:
This meta-analysis showed that these polymorphisms were not significantly associated with T2D. Further studies with large sample size in more diverse geographically regions are needed to improve these findings.
Keywords: rs2910164, rs895819, Type 2 diabetes, Meta-Analysis
     
Type of Study: Review Article | Subject: Biochemistry
Received: 2019/06/20 | Accepted: 2020/01/14 | Published: 2020/05/4
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Karimpour A, Mazare A, Hadianpour S, Molla Agha Zarandi M, Alipoor B. Association of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis. Armaghane danesh. 2020; 25 (2)
URL: http://armaghanj.yums.ac.ir/article-1-2557-en.html


Volume 25, Issue 2 (4-2020) Back to browse issues page
ارمغان دانش Armaghane danesh
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