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:: Volume 24, Issue 4 (9-2019) ::
__Armaghane Danesh__ 2019, 24(4): 0-0 Back to browse issues page
Histological assessment of intera articular injection of 90Y- hydroxyapatite radiocolloid in enrofloxacin induced rheumatoid arthritis in rat models
Hasan Morovvati 1, Mohammad Mazidi Sharaf abadi Seyed2 , Kamal Yavari3
1- University of Tehran , hmorovvati@ut.ac.ir
2- University of Tehran
3- atomic energy organization of iran
Abstract:   (240 Views)
Histological assessment of intera articular injection of 90Y- hydroxyapatite radiocolloid in enrofloxacin induced rheumatoid arthritis in rat models
 
Introduction: Rheumatoid arthritis (RA) is one of the most common and disabling diseases in societies that causes chronic synovial inflammation and joint damages. Several pharmaceutical and non-pharmaceutical treatments of RA have been developed, among which radiosynovectomy using beta-emitting radionuclides is a safe and effective treatment in a patient with no response to drug therapies or systemic drug side effects. In this study, the histological effects of yttrium-90 hydroxyapatite (90Y-HA) injection in the knee joint of RA rat models were assessed.
Methods: Rat models of RA were prepared by intraperitoneal injection of 20 mg/kg enrofloxacin for 15 days. Therapeutic effects of 90Y-HA injection in the knee joint of RA rat models were evaluated via histology staining techniques 2 weeks and 2 months after treatment.
Results: Significant statistical differences (p < 0.05) were observed in such studied parameters as articular cartilage thickness, the number of chondrocytes and lacunae and regeneration of joint cartilage 2 months after intra-articular injection of 90Y-HA in knee joint.
Conclusion: It seems that intra-articular injection of 90Y-HA could be one of the efficient therapies for reducing inflammatory factors and improving the induced RA in rats.
Keywords: Rheumatoid arthritis, Enrofloxacin, Radiosynovectomy, Yttrium-90 hydroxyapatite
 
Keywords: Rheumatoid arthritis, Enrofloxacin, Radiosynovectomy, Yttrium-90 hydroxyapatite
     
Type of Study: Research | Subject: Anatomy
Received: 2019/04/29 | Accepted: 2019/09/2 | Published: 2019/09/21
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Morovvati H, Mazidi Sharaf abadi M, Yavari K. Histological assessment of intera articular injection of 90Y- hydroxyapatite radiocolloid in enrofloxacin induced rheumatoid arthritis in rat models. Armaghane danesh. 2019; 24 (4)
URL: http://armaghanj.yums.ac.ir/article-1-2508-en.html


Volume 24, Issue 4 (9-2019) Back to browse issues page
ارمغان دانش Armaghane danesh
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