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The Effect of Six Weeks of Aerobic Training on Serotonin and Serotonin Receptors Levels in Hippocampus of Depression Female BALB/c Mice with Breast Cancer
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SH Izadpanah1    , MR Kordi 2, R Nouri3 |
1- Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish
2- Department of Exercise Physiology, University of Tehran, Tehran, Iran , mrkordi@ut.ac.ir.com
3- Department of Exercise Physiology, University of Tehran, Tehran, Iran |
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Abstract: (3996 Views) |
Abstract
Background & aim: Breast cancer is the most common type of cancer. On the other hand, the incidence of breast cancer in Iranian women is at least one decade lower than that of women in developed countries. The role of physical activity in the recovery of all types of cancer has been considered. The aim of this study was to determine the effect of six weeks of aerobic training on serotonin and its receptors in the hippocampus of depressed mice with breast cancer.
Methods: In the present experimental study, thirty mice were randomly divided into healthy control, cancer control, and exercise cancer groups. Breast cancer tumors were induced by MC4-L2 cell infusion. Aerobic exercise group were performed treadmill exercise (5 times/week for 6 weeks with duration and intensity of 55min/d and 20m/min respectively in the final weeks). For investigation the depression in this study we used force swim test (FST) before and after training. Forty eight hours after the last exercise session hippocampus tissue samples were obtained. Concentrations of serotonin (pg/ml), 5 HT3R and 5 HT7R were measured by Elisa and RT PCR methods respectively. The data were analyzed using Kolmogorov-Smirnov tests, two-way ANOVA, Bonferroni post hoc analysis.
Results: Statistical analysis indicated significant increase of serotonin levels in exercise cancer group (P=0.001). The mean 5 HT3R and 5 HT7R level of the cancer groups were not significant than that of the healthy control group (p=0.689) and exercise cancer group (p=0.415). The amount of immobility time was significantly lower in the exercise cancer group compared to that in the cancer control group (P=0.001).
Conclusion: In conclusion, breast cancer may lead to reduction of serotonin levels in the hippocampus and increase depression. Furthermore, six weeks of aerobic exercise could increase serotonin level in the hippocampus of the breast cancer mice but were not significant on 5HT3 and 5HT7 receptors. Six weeks of aerobic exercise may decrease depression. More studies are suggested.
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| Keywords: Aerobic Training, Breast cancer, Serotonin, 5-HT3R, 5-HT7R, Depression |
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Full-Text [PDF 172 kb]
(882 Downloads)
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Type of Study: Research |
Subject:
Sport Physiology
Received: 2018/11/18 | Accepted: 2019/05/14 | Published: 2019/07/7
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