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:: Volume 23, Issue 5 (11-2018) ::
__Armaghane Danesh__ 2018, 23(5): 631-642 Back to browse issues page
Down-Regulation Smurf2 (Smad ubiquitin Regulatory Factor 2) Gene in Patients With RRMS and Association With High Disability
F Behdarvand Dehkordi1 , S Reiisi 2, P Mohamadi Nejad3
1- Department of Genetic, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran,
2- Department of Genetic, Shahrekord University, Shahrekord, Iran , s.reiisi@yahoo.com
3- Department of Genetic, Shahrekord University, Shahrekord, Iran
Abstract:   (294 Views)
Background & aim: Multiple sclerosis (MS) is a chronic inflammatory disease in the central nervous system that is associated with degeneration of the myelin of neural system. One of the most important cytokines that are involved in the susceptibility to MS disease is beta-stimulating factor (TGF-β).The smurf2 gene plays an important role in determining the competence of the cell in response to the signaling pathway of TGF- β. Therefore, the aim of this study was to determine the role of the smurf2 gene in this signaling pathway and its association with clinical factors in MS patients.
 
Methods: Blood samples obtained from 50 MS patients and 50 normal. First, 2ml of peripheral blood sample were taken from all patients. Then complementary DNA synthesis (cDNA), relative gene expression was obtained using Real Time PCR method and the data were analyzed by statistical methods.
 
Results: The present study indicated that the relative expression of Smurf2 gene was significantly decreased in MS patients compared with control group) P value= 0.03(.
 
Conclusion: Since smurf2 is a protein involved in the signaling pathway of TGF- β, here the reduction of the expression of smurf2 on this pathway may be such that it affected the pathway initiator primary ligand causing abnormalities in the cell and ultimately may affect neuronal differentiation.
 
 
Keywords: Smurf2, RRMS, Gene Expression
Full-Text [PDF 822 kb]   (80 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/01/20 | Accepted: 2018/11/3 | Published: 2018/11/3
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Behdarvand Dehkordi F, Reiisi S, Mohamadi Nejad P. Down-Regulation Smurf2 (Smad ubiquitin Regulatory Factor 2) Gene in Patients With RRMS and Association With High Disability . Armaghane danesh. 2018; 23 (5) :631-642
URL: http://armaghanj.yums.ac.ir/article-1-2075-en.html


Volume 23, Issue 5 (11-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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