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:: Volume 23, Issue 5 (11-2018) ::
__Armaghane Danesh__ 2018, 23(5): 631-642 Back to browse issues page
Down-regulation Smurf2 (Smad ubiquitin regulatory factor 2) gene in patients with RRMS and association with high disability
Fereshteh Behdarvand Dehkordi Miss1 , Somayeh Reiisi Dr. 2, Parisa Mohammadi nejad Dr.1
1- Islamic Azad University
2- Sciences, Shahrekord University , s.reiisi@yahoo.com
Abstract:   (133 Views)
Background and aim: Multiple sclerosis (MS) is a chronic inflammatory disease in the central nervous system that is associated with degeneration of the myelin of neural system. One of the most important cytokines that are involved in the susceptibility to MS disease is beta-stimulating factor (TGF-B).The smurf2 gene plays an important role in determining the competence of the cell in response to the signaling pathway of TGF-B and since MS is an inflammatory disease.
Materials and methods: Blood samples obtained from 50 MS patients and 50 normal control. First, 2 cc of peripheral blood sample were collected from all patients. Then complementary DNA synthesis (cDNA), relative gene expression was obtained using Real Time PCR method and the data were analyzed by statistical methods.
Results: The present study shows that the relative expression of Smurf2 gene is significantly decreased in MS patients compared with control group) P value= 0/03(.
Conclusion: Since smurf2 is a protein involved in the signaling pathway of TGF-B, here the reduction of the expression of smurf2 on this pathway may be such that it affects the pathway initiator primary ligand causing abnormalities in the cell and ultimately may affect neuronal differentiation.
Keywords: Smurf2, RRMS, Gene expression
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Type of Study: Research | Subject: General
Received: 2018/01/20 | Accepted: 2018/11/3 | Published: 2018/11/3
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Behdarvand Dehkordi F, reiisi S, mohammadi nejad P. Down-regulation Smurf2 (Smad ubiquitin regulatory factor 2) gene in patients with RRMS and association with high disability . Armaghane danesh. 2018; 23 (5) :631-642
URL: http://armaghanj.yums.ac.ir/article-1-2075-en.html

Volume 23, Issue 5 (11-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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