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:: Volume 23, Issue 5 (11-2018) ::
__Armaghane Danesh__ 2018, 23(5): 0-0 Back to browse issues page
Effect of hydroalcoholic extract of Cinnamomum Zeylanicum on changes of ovarian tissue and hormone in the cyclophosemide treated rats
Hatam Mehrani Baynooj 1 , Nabi Allah Gholamzadeh 1 , Roh Allah Ghlandari 1 , Farangis Ghassemi 2
1- Islamic Azad University
2- Islamic Azad University , ghassemi.fr@gmail.com
Abstract:   (52 Views)
​ Introduction and aim: Using of cyclophosphamide with its side effects is required in the treatment of some diseases. Regarding the known value of cinnamon extract, this study aimed to investigate the protective effect of cinnamon against the effects of cyclophosphamide on ovarian function in Rat.

Methods: 49 adult rats were arranged in seven groups. No treatment control group, sham group was injected drug’s solvent, and treatment groups 1, 2, 3 were injected 5 mg/kg/bw Cyclophosphamide daily. These groups were gavaged 0.5, 1, 2 gr /kg /bw Cinnamon extract daily. Groupe 4 was injected 5 mg/kg/bw Cyclophosphamide, and Groupe 5 was gavaged  2gr/kg/bw Cinnamon extract. After 21 days, left ovary of rats was removed and fixed for tissue processing, and 5 micron sections were prepared and studied. The obtained data were analyzed with SPSS (18( and ANOVA, and they were compared with Duncan’s test.

 
Results: The study of prepared photomicrographs of ovarian tissue showed that mean of follicle types and corpus luteum showed a significant decline in the treatment of Cyclophosphamide and Cinnamon extract especially in maximum dose compared to the control group and increase compared to the treatment Cyclophosphamide (P<0.05). The treatment of Cinnamon showed to increase in comparing to other groups. Significantly increase of atretic follicle was observed in the treatment of cyclophosphamide and its decline were seen in other groups. FSH and LH, estrogen and progesterone in the treatment of Cyclophosphamide decreased significantly, and they increased in other treatments.
Conclusion: According to these results, the cinnamon extract with its antioxidant properties has a dose- dependent protective effect on the pituitary-gond axis, and by increasing the number of follicles and the level of ovarian hormones, it reduced the adverse effects of cyclophosphamide in the ovary. Therefore, further research is recommended on generalizing this result to humans.
Keywords: Cinnamon extract, Cyclophosphamide, Ovary, Rat
     
Type of Study: Research | Subject: Physiology
Received: 2018/01/16 | Accepted: 2018/11/20 | Published: 2018/11/20
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Mehrani Baynooj H, Gholamzadeh N A, Ghlandari R A, Ghassemi F. Effect of hydroalcoholic extract of Cinnamomum Zeylanicum on changes of ovarian tissue and hormone in the cyclophosemide treated rats. Armaghane danesh. 2018; 23 (5)
URL: http://armaghanj.yums.ac.ir/article-1-2071-en.html


Volume 23, Issue 5 (11-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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