Background & Aim: Ginger possesses antioxidant properties which modifies oxidative indices. The use of high fat diet and low mobility is one of the reasons for the prevalence of fatty liver disease. Therefore, this study aimed to investigate the effect of ginger extract and physical activity on tissue changes induced by high fat diet and serum liver enzymes in adult male rats.

Methods: In this experimental study, 56 adult male rats in control (non-treated), control (treatment with high fat diet (10 ml / kg) and 5 experimental groups receiving high-fat diet (10 ml / kg) plus Doses of 100 and 200 mg / kg of ginger extract alone and with physical activity on the treadmill were used. Prescriptions were taken 28 days and served as gavage. At the end, after anesthetizing the animals and collecting blood from their hearts, their liver was removed to measure the AST, ALT and ALP enzymes, and after preparation of the tissue sections, the results of liver enzymes were measured by Anova and Duncan tests and significant differences in the data at 0.05 > p was considered.

Results: High fat diet increased AST, ALT and ALP enzymes at the level of p <0.001 and liver tissue damage in comparison to the control group, and ginger and physical activity alone or with each other significantly decreased the AST and ALT enzymes at p >0.01 and ALP at the level of p <0.001 and improve the liver tissue structure compared with the high-fat diet group.

Conclusion: The results showed that high levels of ALT, AST , ALP, liver tissue damage, physical activity and ginger extract alone and in combination decrease ALT, AST and ALP and improve the liver tissue structure. It is better to modify the results based on the results, similar to the findings.