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:: Volume 23, Issue 1 (4-2018) ::
__Armaghane Danesh__ 2018, 23(1): 29-41 Back to browse issues page
The healing effect of Teucriumpolium L. on acetic acid-induced colitis in male Rat
Abstract:   (710 Views)
Background & aim: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, a chronic condition of the intestine with unknown etiology involving different agents immune, genetic and environment. Today, many of herbal and synthetic compounds are being used as anti-inflammatory products around the world. The aim of this study was to investigate the anti-inflammatory effect of aquatic extraction of Teucrium polium L. plant.

Methods: In this experimental study, a total of 135 male rats, weighing 200±20 g and 10  to 12 weeks old, were randomly divided into nine equal groups: healthy control group were given normal saline without ulcerative colitis (UC) induction, negative control group which UC was induced by 3% acetic acid with no treatment, basal gel group which were received basal gel via enema after UC induction, two groups as positive controls were taken Asacol (10 mg/kg/day) and Mesalamine (10 mg/kg/day) transrectally and orally, respectively. Also, oral form of aqueous extraction 50 and 100 mg/kg/day and enema form (gel 10% and 20%) of Teucrium polium L. were given. At the end of study, MDA measurement as antioxidant index and histopathological evaluation of colon tissue was performed. The collected data were analysed using one-way ANOVA and Mann–Whitney U test.

Results: the results showed that groups were received enema gels 10% and 20% compared with other groups significantly repaired damaged tissue of colon at the microscopic level and caused reduction in MDA level (p­<0.01). Gels 20% compared with negative control showed significant difference in decrement of MDA (P=0.01). Mesalamine and Asacol as positive controls with each other, compared with oral forms and enema form of Teucrium polium L. showed no significant difference in respect of MDA (p<0.05). Although, enema gel form compared with oral form of plant aquatic extraction showed no significant difference, enema form had better effect in control of inflammation.                        
Conclusion: Teucrium polium L. has remarkable effects on healing processing of induced colitis in rat. According to anti-inflammation and anti-microbial properties of Teucrium polium L., it can be mentioned that this plant is effective in healing of intestinal ulcers. Also, antioxidant materials of Teucrium polium L. accelerate healing processing.
Keywords: Inflammatory bowel disease, Teucriumpolium L, male rat, colitis
Full-Text [PDF 879 kb]   (68 Downloads)    
Type of Study: Research | Subject: Special
Received: 2017/07/23 | Accepted: 2018/02/7 | Published: 2018/02/26
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The healing effect of Teucriumpolium L. on acetic acid-induced colitis in male Rat. Armaghane danesh. 2018; 23 (1) :29-41
URL: http://armaghanj.yums.ac.ir/article-1-1887-en.html

Volume 23, Issue 1 (4-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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